CRB3 blocking peptide

CRB3 Antibody (Center) Blocking Peptide

• Synonyms: CRB3; CRB3 Antibody (Center) Blocking Peptide; Protein crumbs homolog 3; CRB3 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 120

• Cellular Location: Apical cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note: Localizes primarily to the apical membrane with a small fraction in the upper part of tight junctions of epithelial cells
• Tissue Location: Preferentially expressed in epithelial tissues. Expressed at high levels in lung, kidney, retina, colon and mammary glands. Expressed at moderate levels in liver, spleen, pancreas, placenta and prostate.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CRB3 blocking peptide

Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of tight junctions.

NCBI and Uniprot Product Information

• NCBI GI #: 67460584
• NCBI GeneID: 92359
• UniProt Accession #: Q9BUF7; Q8N0V8; Q8WVA0; A8KA91; D6W643
• Molecular Weight: 13,113 Da
• NCBI Official Full Name: Protein crumbs homolog 3
• NCBI Official Synonym Full Names: crumbs 3, cell polarity complex component
• NCBI Official Symbol: CRB3
• NCBI Protein Information: protein crumbs homolog 3
• UniProt Protein Name: Protein crumbs homolog 3
• Protein Family: Protein crumbs
• UniProt Gene Name: CRB3
• UniProt Entry Name: CRUM3_HUMAN

NCBI Description

This gene encodes a member of the Crumbs family of proteins. This gene is widely expressed in epithelial tissues where the encoded protein isoforms play various roles such as the control of cytokinesis and ciliogenesis or the formation of tight junctions. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

Uniprot Description

CRB3: Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of tight junctions. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: cell junction; plasma membrane

Molecular Function: protein binding; protein domain specific binding; SH3 domain binding