GNA13 blocking peptide

GNA13 Antibody (Center) Blocking Peptide

• Gene Names: GNA13; G13
• Synonyms: GNA13; GNA13 Antibody (Center) Blocking Peptide; Guanine nucleotide-binding protein subunit alpha-13; G alpha-13; G-protein subunit alpha-13; GNA13 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 377

• Cellular Location: Membrane; Lipid-anchor. Melanosome. Cytoplasm. Nucleus. Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Detected in the cytoplasm of Leydig cells and in the seminiferous epithelium, including differentiating cells from the spermatogonia to mature spermatozoa stages. In round spermatids, also present in the nuclei
• Tissue Location: Expressed in testis, including in Leydig cells and in the seminiferous epithelium, in differentiating cells from the spermatogonia to mature spermatozoa stages and round spermatids (at protein level). Expressed in 99.2% of spermatozoa from healthy individuals, but only in 28.6% of macrocephalic spermatozoa from infertile patients (at protein level)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for GNA13 blocking peptide

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

NCBI and Uniprot Product Information

• NCBI GI #: 38258936
• NCBI GeneID: 10672
• UniProt Accession #: Q14344; Q8TD70; B2R977; B7Z7R0; F5H1G8
• Molecular Weight: 33,287 Da
• NCBI Official Full Name: Guanine nucleotide-binding protein subunit alpha-13
• NCBI Official Synonym Full Names: G protein subunit alpha 13
• NCBI Official Symbol: GNA13
• NCBI Official Synonym Symbols: G13
• NCBI Protein Information: guanine nucleotide-binding protein subunit alpha-13
• UniProt Protein Name: Guanine nucleotide-binding protein subunit alpha-13
• Protein Family: Guanine nucleotide-binding protein
• UniProt Gene Name: GNA13
• UniProt Synonym Gene Names: G alpha-13; G-protein subunit alpha-13
• UniProt Entry Name: GNA13_HUMAN

Uniprot Description

G-alpha 13: a guanine nucleotide-binding protein of the G12 class of G-alpha proteins. Activates Rho. Protein kinase A blocks Rho activation by phosphorylation of G-alpha(13). Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Regulates cytoplasmic as well as nuclear signaling events such as activation of the Jun N-terminal kinase signaling module, Na+/H+ exchangers, focal adhesion assemblies, and transcriptional activation of specific primary response genes.

Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(12)

Chromosomal Location of Human Ortholog: 17q24.3

Cellular Component: brush border membrane; cytoplasm; focal adhesion; heterotrimeric G-protein complex; membrane; plasma membrane

Molecular Function: D5 dopamine receptor binding; G-protein beta/gamma-subunit binding; GTPase activity; protein binding; signal transducer activity; type 1 angiotensin receptor binding

Biological Process: cell motility; G-protein signaling, adenylate cyclase activating pathway; phospholipase D activation; platelet activation; Rho protein signal transduction; signal transduction