STEAP3 blocking peptide

STEAP3 Antibody (C-term) Blocking Peptide

• Gene Names: STEAP3; STMP3; TSAP6; pHyde; AHMIO2; dudlin-2; dudulin-2
• Synonyms: STEAP3; STEAP3 Antibody (C-term) Blocking Peptide; Metalloreductase STEAP3; 1161-; Dudulin-2; Six-transmembrane epithelial antigen of prostate 3; Tumor suppressor-activated pathway protein 6; hTSAP6; pHyde; hpHyde; TSAP6; STEAP3 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 488

• Cellular Location: Endosome membrane; Multi-pass membrane protein. Note: Localizes to vesicular-like structures at the plasma membrane and around the nucleus
• Tissue Location: Expressed in adult bone marrow, placenta, liver, skeletal muscle and pancreas. Down-regulated in hepatocellular carcinoma.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for STEAP3 blocking peptide

Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP.

NCBI and Uniprot Product Information

• NCBI GI #: 146325737
• NCBI GeneID: 55240
• UniProt Accession #: Q658P3; Q4VBR2; Q4ZG36; Q53SQ8; Q7Z389; Q86SF6; Q8NEW6; Q8TDP3; Q8TF03; Q9NVB5; A8K6E3
• Molecular Weight: 50,499 Da
• NCBI Official Full Name: Metalloreductase STEAP3
• NCBI Official Synonym Full Names: STEAP3 metalloreductase
• NCBI Official Symbol: STEAP3
• NCBI Official Synonym Symbols: STMP3; TSAP6; pHyde; AHMIO2; dudlin-2; dudulin-2
• NCBI Protein Information: metalloreductase STEAP3
• UniProt Protein Name: Metalloreductase STEAP3
• Protein Family: Metalloreductase
• UniProt Gene Name: STEAP3
• UniProt Synonym Gene Names: TSAP6; hTSAP6; hpHyde
• UniProt Entry Name: STEA3_HUMAN

NCBI Description

This gene encodes a multipass membrane protein that functions as an iron transporter. The encoded protein can reduce both iron (Fe3+) and copper (Cu2+) cations. This protein may mediate downstream responses to p53, including promoting apoptosis. Deficiency in this gene can cause anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

Uniprot Description

STEAP3: a multi-pass membrane protein induced directly by p53. Plays an important role in facilitating exosome secretion. Enhances secretion in the DNA damage-induced p53-dependent exosomal secretory pathway. Localizes to vesicular-like structures at the plasma membrane and around the nucleus. Highly expressed in hematopoietic tissues where it localizes to the specialized endosome. An endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NAD(+) as acceptor. Contains a highly-conserved tyrosine-based motif that has been shown to target transmembrane proteins, including LAMP-1, LAMP-2, the TfR, and SLC11A1 to endosomes, lysosomes, and lysosome-related organelles. Facilitates the exosomal secretion of proteins such as TCTP. Interacts with BNIP3L, MYT1 and TPT1. Four human isoforms are produced by alternative splicing. Isoform 4 is also known as pHyde II.

Protein type: Membrane protein, multi-pass; EC 1.16.1.-; Oxidoreductase; Transporter, iron; Transporter; Membrane protein, integral; Transporter, ion channel

Chromosomal Location of Human Ortholog: 2q14.2

Cellular Component: endosome membrane; integral to plasma membrane; multivesicular body

Molecular Function: cupric reductase activity; oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor; protein binding

Biological Process: copper ion import; protein secretion; regulation of apoptosis; transferrin transport

Disease: Anemia, Hypochromic Microcytic, With Iron Overload 2