Map2k6 blocking peptide
Mouse Map2k6 Antibody (N-term) Blocking Peptide
Gene Names
Map2k6; MEK6; MKK6; Prkmk6; SAPKK3
Synonyms
Map2k6; Mouse Map2k6 Antibody (N-term) Blocking Peptide; Dual specificity mitogen-activated protein kinase kinase 6; MAP kinase kinase 6; MAPKK 6; MAPK/ERK kinase 6; MEK 6; SAPKK3; Prkmk6; Sapkk3; Map2k6 blocking peptide
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
334
Cellular Location
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note: Binds to microtubules.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for Map2k6 blocking peptide
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction; and for IFNG- dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
37,432 Da
NCBI Official Full Name
Dual specificity mitogen-activated protein kinase kinase 6
NCBI Official Synonym Full Names
mitogen-activated protein kinase kinase 6
NCBI Official Symbol
Map2k6
NCBI Official Synonym Symbols
MEK6; MKK6; Prkmk6; SAPKK3
NCBI Protein Information
dual specificity mitogen-activated protein kinase kinase 6
UniProt Protein Name
Dual specificity mitogen-activated protein kinase kinase 6
Protein Family
UniProt Gene Name
Map2k6
UniProt Synonym Gene Names
Prkmk6; Sapkk3; MAP kinase kinase 6; MAPKK 6; MEK 6
UniProt Entry Name
MP2K6_MOUSE
Uniprot Description
MKK6: a dual-specificity protein kinase of the STE7 family. Activates p38 MAP kinase by phosphorylating a Thr and a Tyr residue in the activation loop. Is activated by cytokines and environmental stress in vivo. Three alternatively spliced isoforms have been reported.
Protein type: Protein kinase, dual-specificity (non-receptor); Protein kinase, STE; EC 2.7.12.2; Kinase, protein; STE group; STE7 family
Cellular Component: cytoplasm
Molecular Function: MAP kinase kinase activity; protein binding; protein kinase binding; receptor signaling protein serine/threonine kinase activity
Biological Process: activation of MAPK activity; cardiac muscle contraction; MAPKKK cascade; positive regulation of apoptosis; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of prostaglandin secretion; positive regulation of protein amino acid phosphorylation; protein amino acid phosphorylation
Research Articles on Map2k6
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Product Notes
The Map2k6 map2k6 (Catalog #AAA9221440) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Map2k6, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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