Cdk13 blocking peptide

Mouse Cdk13 Antibody (N-term) Blocking Peptide

• Gene Names: Cdk13; Cdc2l5; 2310015O17Rik
• Synonyms: Cdk13; Mouse Cdk13 Antibody (N-term) Blocking Peptide; Cyclin-dependent kinase 13; CDC2-related protein kinase 5; Cell division cycle 2-like protein kinase 5; Cell division protein kinase 13; Cdc2l5; Kiaa1791; Cdk13 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 1511

• Cellular Location: Nucleus speckle.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Cdk13 blocking peptide

Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis.

NCBI and Uniprot Product Information

• NCBI GI #: 341940539
• NCBI GeneID: 69562
• UniProt Accession #: Q69ZA1; Q80V11; Q8BZG1; Q8K0A4; E9QKZ6
• Molecular Weight: 158,133 Da
• NCBI Official Full Name: Cyclin-dependent kinase 13
• NCBI Official Synonym Full Names: cyclin-dependent kinase 13
• NCBI Official Symbol: Cdk13
• NCBI Official Synonym Symbols: Cdc2l5; 2310015O17Rik
• NCBI Protein Information: cyclin-dependent kinase 13
• UniProt Protein Name: Cyclin-dependent kinase 13
• Protein Family: Cyclin-dependent kinase
• UniProt Gene Name: Cdk13
• UniProt Synonym Gene Names: Cdc2l5; Kiaa1791
• UniProt Entry Name: CDK13_MOUSE

Uniprot Description

CDK13: a CMGC protein kinase of the CDK family. It has been reported to interact with L-type cyclins. Overexpression of CDC2L5 constructs disturbs constitutive splicing and switches alternative splice site selection in vivo suggesting that it may regulate alternative splicing. It has unusually large N- and C-termini and is ubiquitously expressed in many tissues. Two alternatively spliced human isoforms have been described.

Protein type: Kinase, protein; RNA splicing; Motility/polarity/chemotaxis; EC 2.7.11.23; Cell cycle regulation; EC 2.7.11.22; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CMGC; CMGC group; CDK family; CRK7 subfamily; CDK/CRK7 subfamily

Cellular Component: cytoplasm; extracellular space; Golgi apparatus; nuclear cyclin-dependent protein kinase holoenzyme complex; nuclear speck; nucleoplasm

Molecular Function: cyclin binding; RNA polymerase subunit kinase activity

Biological Process: alternative nuclear mRNA splicing, via spliceosome; hemopoiesis