FZD5 blocking peptide

FZD5 Antibody (C-term) Blocking Peptide

• Gene Names: FZD5; HFZ5; C2orf31
• Synonyms: FZD5; FZD5 Antibody (C-term) Blocking Peptide; Frizzled-5; Fz-5; hFz5; FzE5; C2orf31; FZD5 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 585

• Cellular Location: Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein Note: Localized at the plasma membrane and also found at the Golgi
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for FZD5 blocking peptide

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta- catenin pathway.

NCBI and Uniprot Product Information

• NCBI GI #: 116242481
• NCBI GeneID: 7855
• UniProt Accession #: Q13467; Q53R22; A8K2X1; B2RCZ1
• Molecular Weight: 64,507 Da
• NCBI Official Full Name: Frizzled-5
• NCBI Official Synonym Full Names: frizzled class receptor 5
• NCBI Official Symbol: FZD5
• NCBI Official Synonym Symbols: HFZ5; C2orf31
• NCBI Protein Information: frizzled-5
• UniProt Protein Name: Frizzled-5
• Protein Family: Frizzled
• UniProt Gene Name: FZD5
• UniProt Synonym Gene Names: C2orf31; Fz-5; hFz5
• UniProt Entry Name: FZD5_HUMAN

NCBI Description

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD5 protein is believed to be the receptor for the Wnt5A ligand. [provided by RefSeq, Jul 2008]

Uniprot Description

FZD5: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta- catenin pathway. Interacts with GOPC. Belongs to the G-protein coupled receptor Fz/Smo family.

Protein type: Membrane protein, integral; GPCR, Fz/Smo family; Receptor, GPCR; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 2q33.3

Cellular Component: cell surface; early endosome membrane; integral to membrane; plasma membrane

Molecular Function: beta-amyloid binding; G-protein coupled receptor activity; protein binding; protein kinase binding; ubiquitin protein ligase binding; Wnt receptor activity; Wnt-protein binding

Biological Process: determination of anterior/posterior axis, embryo; embryonic axis specification; neuron differentiation; positive regulation of interferon-gamma production; positive regulation of T cell cytokine production; positive regulation of transcription from RNA polymerase II promoter; Spemann organizer formation; synaptogenesis; Wnt receptor signaling pathway through beta-catenin; Wnt receptor signaling pathway, calcium modulating pathway; Wnt receptor signaling pathway, planar cell polarity pathway