Map2k5 blocking peptide

Mouse Map2k5 Antibody (C-term) Blocking peptide

• Gene Names: Map2k5; MEK5; Mapkk5; Prkmk5; AI324775; AI428457
• Synonyms: Map2k5; Mouse Map2k5 Antibody (C-term) Blocking peptide; Dual specificity mitogen-activated protein kinase kinase 5; MAP kinase kinase 5; MAPKK 5; MAPK/ERK kinase 5; MEK 5; Mek5; Mkk5; Prkmk5; Map2k5 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of Mouse Map2k5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 448

• Cellular Location: Cytoplasm.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Map2k5 blocking peptide

Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.

NCBI and Uniprot Product Information

• NCBI GI #: 77416525
• NCBI GeneID: 23938
• UniProt Accession #: Q9WVS7; Q8CFM3; Q8K360; Q9D222
• Molecular Weight: 13,589 Da
• NCBI Official Full Name: Dual specificity mitogen-activated protein kinase kinase 5
• NCBI Official Synonym Full Names: mitogen-activated protein kinase kinase 5
• NCBI Official Symbol: Map2k5
• NCBI Official Synonym Symbols: MEK5; Mapkk5; Prkmk5; AI324775; AI428457
• NCBI Protein Information: dual specificity mitogen-activated protein kinase kinase 5
• UniProt Protein Name: Dual specificity mitogen-activated protein kinase kinase 5
• Protein Family: Dual specificity mitogen-activated protein kinase kinase
• UniProt Gene Name: Map2k5
• UniProt Synonym Gene Names: Mek5; Mkk5; Prkmk5; MAP kinase kinase 5; MAPKK 5; MEK 5
• UniProt Entry Name: MP2K5_MOUSE

Uniprot Description

MEK5: a dual specificity protein kinase of the STE7 family. Activates ERK5 and is itself phosphorylated and activated by MEKK3, as well as by atypical protein kinase C isoforms. Involved in growth factor stimulated cell proliferation and muscle cell differentiation. Four alternatively spliced isoforms have been described.

Protein type: Protein kinase, STE; EC 2.7.12.2; Protein kinase, dual-specificity (non-receptor); Kinase, protein; STE group; STE7 family

Cellular Component: cytoplasm; cytosol; nucleus; spindle

Molecular Function: ATP binding; protein binding; protein kinase activity; receptor signaling protein serine/threonine kinase activity

Biological Process: activation of MAPK activity; heart development; inhibition of NF-kappaB transcription factor; MAPKKK cascade; negative regulation of caspase activity; negative regulation of heterotypic cell-cell adhesion; negative regulation of interleukin-8 biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cell growth; positive regulation of epithelial cell proliferation; positive regulation of protein metabolic process; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation