MMP20 blocking peptide

MMP20 Antibody (C-term) Blocking peptide

• Gene Names: MMP20; AI2A2; MMP-20
• Synonyms: MMP20; MMP20 Antibody (C-term) Blocking peptide; Matrix metalloproteinase-20; MMP-20; 3424-; Enamel metalloproteinase; Enamelysin; MMP20 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of MMP20. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 483

• Cellular Location: Secreted, extracellular space, extracellular matrix
• Tissue Location: Expressed specifically in the enamel organ.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for MMP20 blocking peptide

Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation.

NCBI and Uniprot Product Information

• NCBI GI #: 322510116
• NCBI GeneID: 9313
• UniProt Accession #: O60882; Q6DKT9
• Molecular Weight: 54,387 Da
• NCBI Official Full Name: Matrix metalloproteinase-20
• NCBI Official Synonym Full Names: matrix metallopeptidase 20
• NCBI Official Symbol: MMP20
• NCBI Official Synonym Symbols: AI2A2; MMP-20
• NCBI Protein Information: matrix metalloproteinase-20
• UniProt Protein Name: Matrix metalloproteinase-20
• Protein Family: Matrix metalloproteinase
• UniProt Gene Name: MMP20
• UniProt Synonym Gene Names: MMP-20
• UniProt Entry Name: MMP20_HUMAN

NCBI Description

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene degrades amelogenin, the major protein component of dental enamel matrix, and thus thought to play a role in tooth enamel formation. A mutation in this gene, which alters the normal splice pattern and results in premature termination of the encoded protein, has been associated with amelogenesis imperfecta. This gene is part of a cluster of MMP genes located on chromosome 11q22.3. [provided by RefSeq, Aug 2011]

Uniprot Description

MMP20: Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Defects in MMP20 are the cause of amelogenesis imperfecta hypomaturation type 2A2 (AI2A2). AI2A2 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel. Belongs to the peptidase M10A family.

Protein type: EC 3.4.24.-; Secreted, signal peptide; Secreted; Protease

Chromosomal Location of Human Ortholog: 11q22.3

Cellular Component: extracellular region; extracellular space

Molecular Function: metalloendopeptidase activity; protein binding; serine-type endopeptidase activity

Biological Process: collagen catabolic process

Disease: Amelogenesis Imperfecta, Hypomaturation Type, Iia2