APOBEC1 blocking peptide

Apobec1 Antibody (N-term) Blocking Peptide

• Gene Names: APOBEC1; BEDP; HEPR; CDAR1; APOBEC-1
• Synonyms: Apobec1; Apobec1 Antibody (N-term) Blocking Peptide; C->U-editing enzyme APOBEC-1; 354-; Apolipoprotein B mRNA-editing enzyme 1; HEPR; APOBEC1; APOBEC1 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human Apobec1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 236

• Cellular Location: Cytoplasm.
• Tissue Location: Expressed exclusively in the small intestine.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for APOBEC1 blocking peptide

Catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.

NCBI and Uniprot Product Information

• NCBI GI #: 61743957
• NCBI GeneID: 339
• NCBI Accession #: NP_001635
• NCBI GenBank Nucleotide #: NM_001644.4
• UniProt Accession #: P41238; Q9UE64; Q9UM71
• Molecular Weight: 28,192 Da
• NCBI Official Full Name: C->U-editing enzyme APOBEC-1 isoform a
• NCBI Official Synonym Full Names: apolipoprotein B mRNA editing enzyme catalytic subunit 1
• NCBI Official Symbol: APOBEC1
• NCBI Official Synonym Symbols: BEDP; HEPR; CDAR1; APOBEC-1
• NCBI Protein Information: C->U-editing enzyme APOBEC-1
• UniProt Protein Name: C->U-editing enzyme APOBEC-1
• Protein Family: APOBEC1 complementation factor
• UniProt Gene Name: APOBEC1
• UniProt Entry Name: ABEC1_HUMAN

NCBI Description

This gene encodes a member of the cytidine deaminase enzyme family. The encoded protein forms a multiple-protein editing holoenzyme with APOBEC1 complementation factor (ACF) and APOBEC1 stimulating protein (ASP). This holoenzyme is involved in the editing of C-to-U nucleotide bases in apolipoprotein B and neurofibromatosis-1 mRNAs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2015]

Uniprot Description

APOBEC1: apolipoprotein B mRNA editing enzyme. Responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA. Expressed exclusively in the small intestine.

Protein type: RNA processing; EC 3.5.4.-; Cell cycle regulation; Hydrolase; RNA-binding

Chromosomal Location of Human Ortholog: 12p13.1

Cellular Component: cytoplasm; nucleoplasm

Molecular Function: cytidine deaminase activity; protein binding; RNA binding

Biological Process: cytidine to uridine editing; lipid metabolic process; RNA processing