ANKS1B blocking peptide

ANKS1B Antibody (Center) Blocking peptide

• Gene Names: ANKS1B; EB1; AIDA; EB-1; ANKS2; AIDA-1; cajalin-2
• Synonyms: ANKS1B; ANKS1B Antibody (Center) Blocking peptide; Ankyrin repeat and sterile alpha motif domain-containing protein 1B; Amyloid-beta protein intracellular domain-associated protein 1; AIDA-1; E2A-PBX1-associated protein; EB-1; ANKS1B blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the Center region of ANKS1B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 1248

• Cellular Location: Cytoplasm Isoform 3: Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendritic spine. Nucleus. Nucleus, Cajal body. Note: The synaptic localization requires DLG4 interaction. Translocation to the nucleus in response to stimulation of NMDA receptors (NMDARs) in a calcium-independent manner (By similarity). Isoform 6: Nucleus.
• Tissue Location: Highly expressed in marrow from patients with pre-B ALL associated with the t(1;19) translocation. Strongly expressed in brain and testis. Expressed in fetal brain. Isoform 4 is highly expressed in brain (at protein level). Isoform 6 is expressed in brain and several cancer cell lines
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for ANKS1B blocking peptide

Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells. Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing.

NCBI and Uniprot Product Information

• NCBI GI #: 332278155
• NCBI GeneID: 56899
• UniProt Accession #: Q7Z6G8; Q5XLJ0; Q6IVB5; A5PKY5; A7E259; A8K153; A8MSN4; B4DFP6; B4DH98; F8VPM3; F8VZR9; F8WC27
• Molecular Weight: 44,522 Da
• NCBI Official Full Name: Ankyrin repeat and sterile alpha motif domain-containing protein 1B
• NCBI Official Synonym Full Names: ankyrin repeat and sterile alpha motif domain containing 1B
• NCBI Official Symbol: ANKS1B
• NCBI Official Synonym Symbols: EB1; AIDA; EB-1; ANKS2; AIDA-1; cajalin-2
• NCBI Protein Information: ankyrin repeat and sterile alpha motif domain-containing protein 1B
• UniProt Protein Name: Ankyrin repeat and sterile alpha motif domain-containing protein 1B
• Protein Family: Ankyrin repeat and sterile alpha motif domain-containing protein
• UniProt Gene Name: ANKS1B
• UniProt Synonym Gene Names: AIDA-1; EB-1
• UniProt Entry Name: ANS1B_HUMAN

NCBI Description

This gene encodes a multi-domain protein that is predominantly expressed in brain and testis. This protein interacts with amyloid beta protein precursor (AbetaPP) and may have a role in normal brain development, and in the pathogenesis of Alzheimer's disease. Expression of this gene has been shown to be elevated in patients with pre-B cell acute lymphocytic leukemia associated with t(1;19) translocation. Alternatively spliced transcript variants encoding different isoforms (some with different subcellular localization, PMID:15004329) have been described for this gene. [provided by RefSeq, Aug 2011]

Uniprot Description

AIDA-1b: Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion

Chromosomal Location of Human Ortholog: 12q23.1

Molecular Function: ephrin receptor binding