Related Product Information for TGFBRAP1 blocking peptide
Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2.
NCBI Description
This gene encodes a protein that binds to transforming growth factor-beta (TGF-beta) receptors and plays a role in TGF-beta signaling. The encoded protein acts as a chaprone in signaling downstream of TGF-beta. It is involved in signal-dependent association with SMAD4. The protein is also a component of mammalian CORVET, a multisubunit tethering protein complex that is involved in fusion of early endosomes. [provided by RefSeq, Jun 2016]
Uniprot Description
TGFBRAP1: Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2. Belongs to the TRAP1 family.
Chromosomal Location of Human Ortholog: 2q12.1
Cellular Component: early endosome; membrane
Molecular Function: protein binding; SMAD binding; transforming growth factor beta receptor binding
Biological Process: endosomal vesicle fusion; endosome to lysosome transport; regulation of transcription, DNA-dependent; signal transduction; transforming growth factor beta receptor signaling pathway
Product Notes
The TGFBRAP1 tgfbrap1 (Catalog #
AAA9219886) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
It is sometimes possible for the material contained within the vial of
"TGFBRAP1, Blocking Peptide" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
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