APCDD1 Blocking Peptide | APCDD1 (HGNC:15718) blocking peptide
APCDD1 Antibody (N-term) Blocking peptide
NCBI and Uniprot Product Information
NCBI Description
This locus encodes an inhibitor of the Wnt signaling pathway. Mutations at this locus have been associated with hereditary hypotrichosis simplex. Increased expression of this gene may also be associated with colorectal carcinogenesis.[provided by RefSeq, Sep 2010]
Uniprot Description
APCDD1: a single-pass type I membrane protein. Probably plays a role in colorectal tumorigenesis. Directly activated downstream targets of the WNT/beta-catenin pathway. Transcriptional target of beta-catenin/T-cell (Tcf) factor and may enhance cellular proliferation of tumor cells. Down-regulated by wild-type the adenomatosis polyposis coli (APC) protein. Elevated in many primary colon cancer tissues.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 18p11.22
Cellular Component: integral to plasma membrane
Molecular Function: Wnt-protein binding
Biological Process: hair follicle development; negative regulation of Wnt receptor signaling pathway
Disease: Hypotrichosis 1
Research Articles on APCDD1 (HGNC:15718)
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Product Notes
The APCDD1 (HGNC:15718) apcdd1 (Catalog #AAA9219860) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "APCDD1, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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