Western Blot (WB)
(APCDD1 Antibody (N-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the APCDD1 antibody detected the APCDD1 protein (arrow).)
Rabbit APCDD1 Polyclonal Antibody | anti-APCDD1 antibody
APCDD1 Antibody (N-term)
Western Blot (WB)
(APCDD1 Antibody (N-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the APCDD1 antibody detected the APCDD1 protein (arrow).)
Western Blot (WB)
(APCDD1 Antibody (N-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the APCDD1 antibody detected the APCDD1 protein (arrow).)
Immunohistochemistry (IHC)
(APCDD1 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of APCDD1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(APCDD1 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of APCDD1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
pathway. Mutations at this locus have been associated with
hereditary hypotrichosis simplex. Increased expression of this gene
may also be associated with colorectal carcinogenesis.
Takahashi, M., et al. Cancer Res. 62(20):5651-5656(2002)
NCBI and Uniprot Product Information
NCBI Description
This locus encodes an inhibitor of the Wnt signaling pathway. Mutations at this locus have been associated with hereditary hypotrichosis simplex. Increased expression of this gene may also be associated with colorectal carcinogenesis.[provided by RefSeq, Sep 2010]
Uniprot Description
APCDD1: a single-pass type I membrane protein. Probably plays a role in colorectal tumorigenesis. Directly activated downstream targets of the WNT/beta-catenin pathway. Transcriptional target of beta-catenin/T-cell (Tcf) factor and may enhance cellular proliferation of tumor cells. Down-regulated by wild-type the adenomatosis polyposis coli (APC) protein. Elevated in many primary colon cancer tissues.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 18p11.22
Cellular Component: integral to plasma membrane
Molecular Function: Wnt-protein binding
Biological Process: negative regulation of Wnt receptor signaling pathway; Wnt receptor signaling pathway; hair follicle development; astrocyte cell migration
Disease: Hypotrichosis 1
Research Articles on APCDD1
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Product Notes
The APCDD1 apcdd1 (Catalog #AAA9207735) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 69-98. The APCDD1 Antibody (N-term) reacts with Human (Predicted Reactivity: Xenopus) and may cross-react with other species as described in the data sheet. AAA Biotech's APCDD1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the APCDD1 apcdd1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "APCDD1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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