WDR45L Blocking Peptide | WDR45B blocking peptide

WDR45L Antibody (N-term) Blocking peptide

• Gene Names: WDR45B; WIPI3; WDR45L; WIPI-3
• Synonyms: WDR45L; WDR45L Antibody (N-term) Blocking peptide; WD repeat domain phosphoinositide-interacting protein 3; WIPI-3; WD repeat-containing protein 45-like; WDR45-like protein; WD repeat-containing protein 45B; WIPI49-like protein; WDR45B; WIPI3; WDR45B blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the N-term region of WDR45L. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 344

• Tissue Location: Ubiquitously expressed. Highly expressed in heart, skeletal muscle and pancreas. Up-regulated in a variety of tumor tissues including ovarian and uterine cancers
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 85542094
• NCBI GeneID: 56270
• UniProt Accession #: Q5MNZ6; O95328; Q2MCP6; Q6IBN2
• Molecular Weight: 38,122 Da
• NCBI Official Full Name: WD repeat domain phosphoinositide-interacting protein 3
• NCBI Official Synonym Full Names: WD repeat domain 45B
• NCBI Official Symbol: WDR45B
• NCBI Official Synonym Symbols: WIPI3; WDR45L; WIPI-3
• NCBI Protein Information: WD repeat domain phosphoinositide-interacting protein 3
• UniProt Protein Name: WD repeat domain phosphoinositide-interacting protein 3
• Protein Family: WD repeat domain phosphoinositide-interacting protein
• UniProt Gene Name: WDR45B
• UniProt Synonym Gene Names: WDR45L; WIPI3; WIPI-3; WDR45-like protein
• UniProt Entry Name: WIPI3_HUMAN

NCBI Description

This gene encodes a member of the WIPI or SVP1 family of WD40 repeat-containing proteins. The protein contains seven WD40 repeats that are thought to fold into a beta-propeller structure that mediates protein-protein interactions, and a conserved motif for interaction with phospholipids. The human genome contains several pseudogenes of this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

WDR45B: an ubiquitously expressed WD40 repeat protein. Up-regulated in a variety of tumor tissues including ovarian and uterine cancers. WD40 repeats are found in a number of eukaryotic proteins that coordinate multi-protein complex assemblies. WD40 proteins are implicated in many functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: cytosol; extrinsic to membrane; pre-autophagosomal structure membrane

Molecular Function: phosphatidylinositol 3-phosphate binding

Biological Process: autophagic vacuole formation; mitochondrion degradation; protein amino acid lipidation