XYLT1 blocking peptide

XYLT1 Antibody (N-term) Blocking peptide

• Gene Names: XYLT1; XT1; XTI; XT-I; DBQD2; XYLTI; PXYLT1; xylT-I
• Synonyms: XYLT1; XYLT1 Antibody (N-term) Blocking peptide; Xylosyltransferase 1; Peptide O-xylosyltransferase 1; Xylosyltransferase I; XT-I; XylT-I; XT1; XYLT1 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 959

• Cellular Location: Endoplasmic reticulum membrane; Single-pass type II membrane protein Golgi apparatus membrane; Single- pass type II membrane protein. Secreted. Note: Some fraction is also found in the extracellular space together with chondroitin sulfate proteoglycans, suggesting that it can be secreted
• Tissue Location: Widely expressed. Expressed at higher level in placenta, kidney and pancreas. Weakly expressed in skeletal muscle.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for XYLT1 blocking peptide

Catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes.

NCBI and Uniprot Product Information

• NCBI GI #: 71164803
• NCBI GeneID: 64131
• UniProt Accession #: Q86Y38; Q9H1B6
• Molecular Weight: 107,569 Da
• NCBI Official Full Name: Xylosyltransferase 1
• NCBI Official Synonym Full Names: xylosyltransferase 1
• NCBI Official Symbol: XYLT1
• NCBI Official Synonym Symbols: XT1; XTI; XT-I; DBQD2; XYLTI; PXYLT1; xylT-I
• NCBI Protein Information: xylosyltransferase 1
• UniProt Protein Name: Xylosyltransferase 1
• Protein Family: Xylosyltransferase
• UniProt Gene Name: XYLT1
• UniProt Synonym Gene Names: XT1; XT-I; XylT-I
• UniProt Entry Name: XYLT1_HUMAN

NCBI Description

This locus encodes a xylosyltransferase enzyme. The encoded protein catalyzes transfer of UDP-xylose to serine residues of an acceptor protein substrate. This transfer reaction is necessary for biosynthesis of glycosaminoglycan chains. Mutations in this gene have been associated with increased severity of pseudoxanthoma elasticum.[provided by RefSeq, Nov 2009]

Uniprot Description

XYLT1: Catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes. Belongs to the glycosyltransferase 14 family. XylT subfamily.

Protein type: Glycan Metabolism - heparan sulfate biosynthesis; Transferase; EC 2.4.2.26; Membrane protein, integral; Glycan Metabolism - chondroitin sulfate biosynthesis

Chromosomal Location of Human Ortholog: 16p12.3

Cellular Component: Golgi membrane

Molecular Function: protein xylosyltransferase activity

Biological Process: glycosaminoglycan biosynthetic process

Disease: Desbuquois Dysplasia 2; Pseudoxanthoma Elasticum