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WHSC1L1 blocking peptide

WHSC1L1 Antibody (N-term) Blocking peptide

Gene Names
WHSC1L1; NSD3; WHISTLE; pp14328
Synonyms
WHSC1L1; WHSC1L1 Antibody (N-term) Blocking peptide; Histone-lysine N-methyltransferase NSD3; Nuclear SET domain-containing protein 3; Protein whistle; WHSC1-like 1 isoform 9 with methyltransferase activity to lysine; Wolf-Hirschhorn syndrome candidate 1-like protein 1; WHSC1-like protein 1; NSD3; WHSC1L1 blocking peptide
Ordering
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
1437
Cellular Location
Nucleus. Chromosome
Tissue Location
Highly expressed in brain, heart and skeletal muscle. Expressed at lower level in liver and lung
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for WHSC1L1 blocking peptide
Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
Molecular Weight
160,314 Da
NCBI Official Full Name
Histone-lysine N-methyltransferase NSD3
NCBI Official Synonym Full Names
Wolf-Hirschhorn syndrome candidate 1-like 1
NCBI Official Symbol
WHSC1L1
NCBI Official Synonym Symbols
NSD3; WHISTLE; pp14328
NCBI Protein Information
histone-lysine N-methyltransferase NSD3
UniProt Protein Name
Histone-lysine N-methyltransferase NSD3
UniProt Gene Name
WHSC1L1
UniProt Synonym Gene Names
NSD3; WHSC1-like protein 1
UniProt Entry Name
NSD3_HUMAN

NCBI Description

This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. Two alternatively spliced variants have been described. [provided by RefSeq, May 2015]

Uniprot Description

WHSC1L1: is related to the Wolf-Hirschhorn syndrome candidate-1 protein containing PWWP (proline-tryptophan-tryptophan-proline) domains. The function of the protein has not been determined. Two alternatively spliced isoforms have been described.

Protein type: EC 2.1.1.43; Oncoprotein; Amino Acid Metabolism - lysine degradation; Methyltransferase; Histone-binding; Methyltransferase, protein lysine

Chromosomal Location of Human Ortholog: 8p11.2

Cellular Component: nucleoplasm; nucleus

Molecular Function: histone-lysine N-methyltransferase activity; protein binding

Biological Process: histone methylation

Disease: Leukemia, Acute Myeloid

Research Articles on WHSC1L1

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Product Notes

The WHSC1L1 whsc1l1 (Catalog #AAA9219382) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "WHSC1L1, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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