PLA2G2D blocking peptide

PLA2G2D Antibody (C-term) Blocking peptide

• Gene Names: PLA2G2D; SPLASH; sPLA2S; PLA2IID; sPLA2-IID
• Synonyms: PLA2G2D; PLA2G2D Antibody (C-term) Blocking peptide; Group IID secretory phospholipase A2; GIID sPLA2; sPLA2-IID; PLA2IID; Phosphatidylcholine 2-acylhydrolase 2D; Secretory-type PLA; stroma-associated homolog; SPLASH; PLA2G2D blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 145

• Function: Secretory calcium-dependent phospholipase A2 that primarily targets extracellular lipids, exerting anti-inflammatory and immunosuppressive functions (PubMed:10455175, PubMed: 10681567). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidyl glycerols overphosphatidylcholines (PubMed: 10455175). In draining lymph nodes, selectively hydrolyzes diacyl and alkenyl forms of phosphatidylethanolamines, releasing omega-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoate and docosahexaenoate that are precursors of the anti-inflammatory lipid mediators, resolvins (By similarity). During the resolution phase of acute inflammation drives docosahexaenoate-derived resolvin D1 synthesis, which suppresses dendritic cell activation and T-helper 1 immune response (By similarity). May act in an autocrine and paracrine manner (By similarity). Via a mechanism independent of its catalytic activity, promotes differentiation of regulatory T cells (Tregs) and participates in the maintenance of immune tolerance (By similarity). May contribute to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane (By similarity).
• Cellular Location: Secreted.
• Tissue Location: Highly expressed in pancreas and spleen and less abundantly in colon, thymus, placenta, small intestine, and prostate
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for PLA2G2D blocking peptide

PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. L-alpha-1-palmitoyl-2- linoleoyl phosphatidylethanolamine is more efficiently hydrolyzed than the other phospholipids examined.

NCBI and Uniprot Product Information

• NCBI GI #: 20139286
• NCBI GeneID: 26279
• UniProt Accession #: Q9UNK4; Q9UK01; A8K2Z1; B1AEL9
• NCBI Official Full Name: Group IID secretory phospholipase A2
• NCBI Official Synonym Full Names: phospholipase A2 group IID
• NCBI Official Symbol: PLA2G2D
• NCBI Official Synonym Symbols: SPLASH; sPLA2S; PLA2IID; sPLA2-IID
• NCBI Protein Information: group IID secretory phospholipase A2
• UniProt Protein Name: Group IID secretory phospholipase A2
• Protein Family: Group IID secretory phospholipase
• UniProt Gene Name: PLA2G2D
• UniProt Synonym Gene Names: SPLASH; GIID sPLA2; sPLA2-IID
• UniProt Entry Name: PA2GD_HUMAN

NCBI Description

This gene encodes a secreted member of the phospholipase A2 family, and is found in a cluster of related family members on chromosome 1. Phospholipase A2 family members hydrolyze the sn-2 fatty acid ester bond of glycerophospholipids to produce lysophospholipids and free fatty acid. This gene may be involved in inflammation and immune response, and in weight loss associated with chronic obstructive pulmonary disease. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]

Uniprot Description

PLA2G2D: PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. L-alpha-1-palmitoyl-2- linoleoyl phosphatidylethanolamine is more efficiently hydrolyzed than the other phospholipids examined. Belongs to the phospholipase A2 family.

Protein type: EC 3.1.1.4; Phospholipase; Secreted; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - ether lipid; Secreted, signal peptide; Lipid Metabolism - linoleic acid; Lipid Metabolism - arachidonic acid; Lipid Metabolism - alpha-linolenic acid

Chromosomal Location of Human Ortholog: 1p36.12

Cellular Component: extracellular region

Molecular Function: phospholipase A2 activity

Biological Process: inflammatory response; phosphatidic acid biosynthetic process; phospholipid metabolic process