CD31 Blocking Peptide | Pecam1 blocking peptide

Mouse CD31 Antibody (C-term) Blocking peptide

• Gene Names: Pecam1; Cd31; Pecam; C85791; PECAM-1
• Synonyms: CD31; Mouse CD31 Antibody (C-term) Blocking peptide; Platelet endothelial cell adhesion molecule; PECAM-1; Pecam1; Pecam; Pecam-1; Pecam1 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 727

• Cellular Location: Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell junction Note: Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.
• Tissue Location: Isoform 1 and isoform 3 are expressed in lung and platelets.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Pecam1 blocking peptide

Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-679 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Modulates BDKRB2 activation (By similarity). Induces susceptibility to atherosclerosis.

NCBI and Uniprot Product Information

• NCBI GI #: 585658
• NCBI GeneID: 18613
• UniProt Accession #: Q08481; Q3TES6; Q922E0; B1ARB1; B1ARB2
• Molecular Weight: 69,823 Da
• NCBI Official Full Name: Platelet endothelial cell adhesion molecule
• NCBI Official Synonym Full Names: platelet/endothelial cell adhesion molecule 1
• NCBI Official Symbol: Pecam1
• NCBI Official Synonym Symbols: Cd31; Pecam; C85791; PECAM-1
• NCBI Protein Information: platelet endothelial cell adhesion molecule
• UniProt Protein Name: Platelet endothelial cell adhesion molecule
• Protein Family: Platelet endothelial cell adhesion molecule
• UniProt Gene Name: Pecam1
• UniProt Synonym Gene Names: Pecam; Pecam-1; PECAM-1
• UniProt Entry Name: PECA1_MOUSE

Uniprot Description

PECAM-1: a cell adhesion molecule expressed on platelets and at endothelial cell intercellular junctions. Plays a role in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, cell migration, negative regulation of immune cell signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. Undergoes alternative splicing, generating multiple isoforms in vascular beds of various tissues.

Protein type: Membrane protein, integral; Cell adhesion

Cellular Component: cell surface; external side of plasma membrane; extracellular space; lipid raft; membrane; plasma membrane; smooth muscle contractile fiber

Molecular Function: protein binding

Biological Process: angiogenesis; diapedesis; endothelial cell migration; endothelial cell morphogenesis; negative regulation of actin filament polymerization; negative regulation of peptidyl-tyrosine phosphorylation; phagocytosis; positive regulation of leukocyte migration; positive regulation of tyrosine phosphorylation of Stat5 protein; regulation of cell migration; Rho protein signal transduction; wound healing