Rabbit anti-Human CD3d Polyclonal Antibody | anti-CD3D antibody

CD3d Antibody

Cat. Num. AAA9215994

• Gene Names: CD3D; T3D; IMD19; CD3-DELTA
• Reactivity: Human
• Applications: Western Blot
• Synonyms: CD3d; Polyclonal Antibody; CD3d Antibody; Purified Rabbit Polyclonal Antibody (Pab); T-cell surface glycoprotein CD3 delta chain; T-cell receptor T3 delta chain; CD3D; T3D; anti-CD3D antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Form/Format: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
• Sequence Length: 171

• Applicable Applications for anti-CD3D antibody: Western Blot (WB)
• Application Notes: WB ~~1:500
• Antigen Source: Human
• Antigen Type: A Synthesized Peptide
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(All lanes : Anti-CD3d Antibody at 1:500 dilutionLane 1: Jurkat whole cell lysateLane 2: MOLT-4 whole cell lysateLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution.Predicted band size : 19 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)

Related Product Information for anti-CD3D antibody

The CD3 complex mediates signal transduction.

Product Categories/Family for anti-CD3D antibody

Cancer; Immunology; Stem cells

References

van den Elsen P.,et al.Proc. Natl. Acad. Sci. U.S.A. 83:2944-2948(1986). van den Elsen P.,et al.Nature 312:413-418(1984). Tunnacliffe A.,et al.EMBO J. 5:1245-1252(1986). Jin P.,et al.Genomics 83:566-571(2004). Taylor T.D.,et al.Nature 440:497-500(2006).

NCBI and Uniprot Product Information

• NCBI GI #: 4502669
• NCBI GeneID: 915
• NCBI Accession #: NP_000723.1
• NCBI GenBank Nucleotide #: NM_000732.4
• UniProt Accession #: P04234; A8MVP6
• Molecular Weight: 18930
• NCBI Official Full Name: T-cell surface glycoprotein CD3 delta chain isoform A
• NCBI Official Synonym Full Names: CD3d molecule, delta (CD3-TCR complex)
• NCBI Official Symbol: CD3D
• NCBI Official Synonym Symbols: T3D; IMD19; CD3-DELTA
• NCBI Protein Information: T-cell surface glycoprotein CD3 delta chain
• UniProt Protein Name: T-cell surface glycoprotein CD3 delta chain
• Protein Family: T-cell surface glycoprotein
• UniProt Gene Name: CD3D
• UniProt Synonym Gene Names: T3D
• UniProt Entry Name: CD3D_HUMAN

NCBI Description

The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. [provided by RefSeq, Feb 2009]

Uniprot Description

CD3D: a T cell surface glycoprotein that is a component of the T cell antigen receptor. A defect in this protein causes a severe combined immunodeficiency characterized by the absence of T cells but normal B cells. Contains 1 ITAM domain.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 11q23

Cellular Component: T cell receptor complex; cytoplasm; integral to membrane; plasma membrane; alpha-beta T cell receptor complex

Molecular Function: transmembrane receptor activity; protein heterodimerization activity; transcription coactivator activity

Biological Process: regulation of immune response; cell surface receptor linked signal transduction; T cell costimulation; positive regulation of transcription from RNA polymerase II promoter; T cell receptor signaling pathway; positive thymic T cell selection; T cell differentiation

Disease: Immunodeficiency 19