Mouse 4E-BP2 Monoclonal Antibody | anti-EIF4EBP2 antibody

4E-BP2 Antibody

Cat. Num. AAA9215385

• Gene Names: EIF4EBP2; 4EBP2; PHASII
• Applications: Western Blot
• Synonyms: 4E-BP2; Monoclonal Antibody; 4E-BP2 Antibody; Purified Mouse Monoclonal Antibody (Mab); 4EBP2; 4EBP2_HUMAN; eIF4E binding protein 2; eIF4E-binding protein 2; Eif4ebp2; Eukaryotic translation initiation factor 4E binding protein 1; Eukaryotic translation initiation factor 4E-binding protein 2; PHASII; phosphorylated; heat and acid stable regulated by insulin protein II.; anti-EIF4EBP2 antibody

• Host: Mouse
• Clonality: Monoclonal
• Form/Format: Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.03% Proclin300 and 50% glycerol.
• Sequence Length: 120

• Applicable Applications for anti-EIF4EBP2 antibody: Western Blot (WB)
• Application Notes: WB ~~ 1:1000
• Antigen Source: Human
• Antigen Type: Recombinant Protein
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(Western blot detection of 4E-BP2 in CHO-K1 cell lysate(A)and CHO-K1 transfected by EGFP-4E-BP2 (B)cell lysate using 4E-BP2 mouse mAb (1:1000 diluted).)

Related Product Information for anti-EIF4EBP2 antibody

Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase pathway.

Product Categories/Family for anti-EIF4EBP2 antibody

Metabolism

References

Pause A.,et al.Nature 371:762-767(1994). Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Gauci S.,et al.Anal. Chem. 81:4493-4501(2009). Mayya V.,et al.Sci. Signal. 2:RA46-RA46(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 4758260
• NCBI GeneID: 1979
• NCBI Accession #: NP_004087.1
• NCBI GenBank Nucleotide #: NM_004096.4
• UniProt Accession #: Q13542
• Molecular Weight: 12939
• NCBI Official Full Name: eukaryotic translation initiation factor 4E-binding protein 2
• NCBI Official Synonym Full Names: eukaryotic translation initiation factor 4E binding protein 2
• NCBI Official Symbol: EIF4EBP2
• NCBI Official Synonym Symbols: 4EBP2; PHASII
• NCBI Protein Information: eukaryotic translation initiation factor 4E-binding protein 2
• UniProt Protein Name: Eukaryotic translation initiation factor 4E-binding protein 2
• Protein Family: Eukaryotic translation initiation factor 4E-binding protein
• UniProt Gene Name: EIF4EBP2
• UniProt Synonym Gene Names: eIF4E-binding protein 2
• UniProt Entry Name: 4EBP2_HUMAN

NCBI Description

This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products of this family bind eIF4E and inhibit translation initiation. However, insulin and other growth factors can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of protein production through these gene products have been implicated in cell proliferation, cell differentiation and viral infection. [provided by RefSeq, Oct 2008]

Uniprot Description

4E-BP2: eukaryotic translation initiation factor 4E binding protein 2

Protein type: Translation initiation; Translation

Chromosomal Location of Human Ortholog: 10q21-q22

Cellular Component: cytoplasm

Molecular Function: protein binding; translation repressor activity; eukaryotic initiation factor 4E binding

Biological Process: regulation of synaptic transmission; cAMP-mediated signaling; negative regulation of translational initiation; TOR signaling pathway; translation; insulin receptor signaling pathway; regulation of synaptic plasticity; social behavior; memory