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Western Blot (WB) (TOR2A Antibody (Center) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the TOR2A antibody detected the TOR2A protein (arrow).)

Rabbit TOR2A Polyclonal Antibody | anti-TOR2A antibody

TOR2A Antibody (Center)

Gene Names
TOR2A; TORP1
Reactivity
Human (Predicted Reactivity: Rat)
Applications
Western Blot, ELISA, Immunohistochemistry
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
TOR2A; Polyclonal Antibody; TOR2A Antibody (Center); Torsin-2A; Torsin family 2 member A; Torsin-related protein 1; TORP1; anti-TOR2A antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human (Predicted Reactivity: Rat)
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This TOR2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 194-221 amino acids from the Central region of human TOR2A.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (varies by lot)
Sequence Positions
194-221
Sequence Length
242
Applicable Applications for anti-TOR2A antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)
Application Notes
WB~~1:1000
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(TOR2A Antibody (Center) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the TOR2A antibody detected the TOR2A protein (arrow).)

Western Blot (WB) (TOR2A Antibody (Center) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the TOR2A antibody detected the TOR2A protein (arrow).)

Immunohistochemistry (IHC)

(TOR2A Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TOR2A Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)

Immunohistochemistry (IHC) (TOR2A Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TOR2A Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
Related Product Information for anti-TOR2A antibody
Salusins are multifunctional bioactive peptides discovered by bioinformatics analyses of a full-length cDNA library. Salusin alpha and salusin beta are related peptides of 28 and 20 amino acids that were recently characterized. These peptides are considered to be biosynthesized from preprosalusin, an alternative-splicing product of the torsion dystonia-related gene (TOR2A), after frameshift reading and digestion at dibasic amino acids. Salusin alpha has recently been shown to be involved in atherosclerosis; it potently suppresses acyl-CoA:cholesterol acyltransferase-1 which stores cholesterol ester converted from free cholesterol in macrophages, thereby reducing human macrophage foam cell formation.
Product Categories/Family for anti-TOR2A antibody
References
O'Farrell, C.A., et al. Neuroscience 164(3):1127-1137(2009)
Sato, K., et al. Peptides 29(12):2203-2207(2008)
Watanabe, T., et al. Hypertens. Res. 31(3):463-468(2008)
Wang, Z., et al. Eur. J. Pharmacol. 539(3):145-150(2006)
Humphray, S.J., et al. Nature 429(6990):369-374(2004)

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI GenBank Nucleotide #
Molecular Weight
35714
NCBI Official Full Name
prosalusin isoform a
NCBI Official Synonym Full Names
torsin family 2, member A
NCBI Official Symbol
TOR2A
NCBI Official Synonym Symbols
TORP1
NCBI Protein Information
prosalusin
UniProt Protein Name
Torsin-2A
Protein Family
UniProt Gene Name
TOR2A
UniProt Synonym Gene Names
TORP1
UniProt Entry Name
TOR2A_HUMAN

NCBI Description

This gene encodes a member of the AAA family of adenosine triphosphatases with similarity to Clp proteases and heat shock proteins. Alternative splicing at this locus results in the translation of multiple isoforms of the encoded protein, some of which contain salusin peptides in the C-terminal region. These peptides may play roles in hypotension, myocardial growth and the induction of mitogenesis, and may also be involved in the pathogenesis of atherosclerosis. The antimicrobial peptide salusin-beta has antibacterial activity. [provided by RefSeq, Nov 2014]

Uniprot Description

TOR2A: Salusins -alpha and -beta may be endocrine and/or paracrine factors able to increase intracellular calcium concentrations and induce cell mitogenesis. Salusins may also be potent hypotensive peptides. Belongs to the clpA/clpB family. Torsin subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9q34.11

Cellular Component: endoplasmic reticulum lumen; extracellular region

Molecular Function: hormone activity; ATP binding

Biological Process: chaperone cofactor-dependent protein folding; protein homooligomerization

Research Articles on TOR2A

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Product Notes

The TOR2A tor2a (Catalog #AAA9214404) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 194-221. The TOR2A Antibody (Center) reacts with Human (Predicted Reactivity: Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's TOR2A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the TOR2A tor2a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TOR2A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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