Western Blot (WB)
(Mouse Pik3r1 Antibody (N-term) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the Mouse Pik3r1 antibody detected the Mouse Pik3r1 protein (arrow).)
Rabbit Pik3r1 Polyclonal Antibody | anti-Pik3r1 antibody
Mouse Pik3r1 Antibody (N-term)
Western Blot (WB)
(Mouse Pik3r1 Antibody (N-term) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the Mouse Pik3r1 antibody detected the Mouse Pik3r1 protein (arrow).)
Western Blot (WB)
(Mouse Pik3r1 Antibody (N-term) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the Mouse Pik3r1 antibody detected the Mouse Pik3r1 protein (arrow).)
NCBI and Uniprot Product Information
Uniprot Description
PIK3R1: regulatory subunit of phosphoinositide-3-kinase. Mediates binding to a subset of tyrosine-phosphorylated proteins through its SH2 domain. Acts as an adapter, mediating the association of the p110 catalytic unit of the alpha, beta and delta enzymes to the plasma membrane, where p110 phosphorylates inositol lipids. May play an additional role in the regulation of the actin cytoskeleton. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Its SH2 domains interacts with the YTHM motif of phosphorylated INSR in vitro. Defects in PIK3R1 are a cause of severe insulin resistance. Four alternatively spliced isoforms have been described.
Protein type: Enzyme, regulatory subunit; Motility/polarity/chemotaxis; Kinase, lipid
Cellular Component: neuron projection; protein complex; membrane; cell; cytoplasm; plasma membrane; intercellular junction; intracellular; phosphoinositide 3-kinase complex; cytosol; nucleus
Molecular Function: protein C-terminus binding; protein domain specific binding; neurotrophin TRKA receptor binding; 1-phosphatidylinositol-3-kinase activity; platelet-derived growth factor receptor binding; phosphoprotein binding; phosphoinositide 3-kinase regulator activity; 1-phosphatidylinositol-3-kinase regulator activity; receptor tyrosine kinase binding; protein kinase binding; protein phosphatase binding; transcription factor binding; ATPase binding; insulin receptor binding; calmodulin binding; insulin binding; insulin-like growth factor receptor binding; protein binding; ErbB-3 class receptor binding; protein heterodimerization activity; insulin receptor substrate binding; ubiquitin protein ligase binding; phosphoinositide 3-kinase binding; estrogen receptor binding; receptor binding
Biological Process: negative regulation of osteoclast differentiation; phosphoinositide 3-kinase cascade; negative regulation of heart rate; response to cAMP; negative regulation of smooth muscle cell proliferation; response to glucocorticoid stimulus; signal transduction; positive regulation of RNA splicing; protein amino acid phosphorylation; NFAT protein import into nucleus; regulation of phosphoinositide 3-kinase activity; response to insulin stimulus; protein transport; phosphoinositide phosphorylation; transport; positive regulation of transcription factor import into nucleus; negative regulation of blood pressure; negative regulation of proteolysis; protein stabilization; glucose metabolic process; negative regulation of cell-matrix adhesion; positive regulation of tumor necrosis factor production; positive regulation of myoblast differentiation; DNA damage response, signal transduction resulting in induction of apoptosis; insulin-like growth factor receptor signaling pathway; cellular response to insulin stimulus; induction of apoptosis via death domain receptors; B cell differentiation; insulin receptor signaling pathway; cell glucose homeostasis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of cell-cell adhesion; positive regulation of protein amino acid phosphorylation; positive regulation of cell migration; negative regulation of apoptosis
Research Articles on Pik3r1
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Product Notes
The Pik3r1 pik3r1 (Catalog #AAA9213829) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 56-84. The Mouse Pik3r1 Antibody (N-term) reacts with Mouse (Predicted Reactivity: Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's Pik3r1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the Pik3r1 pik3r1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Pik3r1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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