Western Blot (WB)
(TGFBRAP1 Antibody (C-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the TGFBRAP1 antibody detected the TGFBRAP1 protein (arrow).)
Rabbit anti-Human TGFBRAP1 Polyclonal Antibody | anti-TGFBRAP1 antibody
TGFBRAP1 Antibody (C-term)
Gene Names
TGFBRAP1; TRAP1; TRAP-1
Reactivity
Human
Applications
Western Blot, ELISA, Immunohistochemistry
Purity
This antibody is purified through a protein A column, followed by peptide affinity purification.
Synonyms
TGFBRAP1; Polyclonal Antibody; TGFBRAP1 Antibody (C-term); Transforming growth factor-beta receptor-associated protein 1; TGF-beta receptor-associated protein 1; TRAP-1; TRAP1; anti-TGFBRAP1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This TGFBRAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 499-528 amino acids from the C-terminal region of human TGFBRAP1.
Purity/Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Sequence Positions
499-528
Sequence Length
860
Applicable Applications for anti-TGFBRAP1 antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry-paraffin (IHC-p)
Application Notes
WB~~1:1000
IHC-P~~1:10~50
IHC-P~~1:10~50
Function
Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes mainly through the type II receptor, and is released upon activation of signaling . May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2.
Cellular Location
Cytoplasm. Early endosome. Note= Colocalizes with TGF-beta receptors in the absence of signaling.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Western Blot (WB)
(TGFBRAP1 Antibody (C-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the TGFBRAP1 antibody detected the TGFBRAP1 protein (arrow).)
Western Blot (WB)
(TGFBRAP1 Antibody (C-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the TGFBRAP1 antibody detected the TGFBRAP1 protein (arrow).)
Immunohistochemistry (IHC)
(TGFBRAP1 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TGFBRAP1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(TGFBRAP1 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TGFBRAP1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Related Product Information for anti-TGFBRAP1 antibody
TGFBRAP1 plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2.
Product Categories/Family for anti-TGFBRAP1 antibody
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Le Clerc, S., et al. J. Infect. Dis. 200(8):1194-1201(2009)
Hwang, Y., et al. Pharmacogenomics 7(5):697-709(2006)
Wurthner, J.U., et al. J. Biol. Chem. 276(22):19495-19502(2001)
Provost, P., et al. Proc. Natl. Acad. Sci. U.S.A. 96(5):1881-1885(1999)
Le Clerc, S., et al. J. Infect. Dis. 200(8):1194-1201(2009)
Hwang, Y., et al. Pharmacogenomics 7(5):697-709(2006)
Wurthner, J.U., et al. J. Biol. Chem. 276(22):19495-19502(2001)
Provost, P., et al. Proc. Natl. Acad. Sci. U.S.A. 96(5):1881-1885(1999)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
97158
NCBI Official Full Name
transforming growth factor-beta receptor-associated protein 1
NCBI Official Synonym Full Names
transforming growth factor, beta receptor associated protein 1
NCBI Official Symbol
TGFBRAP1
NCBI Official Synonym Symbols
TRAP1; TRAP-1
NCBI Protein Information
transforming growth factor-beta receptor-associated protein 1
UniProt Protein Name
Transforming growth factor-beta receptor-associated protein 1
Protein Family
UniProt Gene Name
TGFBRAP1
UniProt Synonym Gene Names
TGF-beta receptor-associated protein 1; TRAP-1; TRAP1
UniProt Entry Name
TGFA1_HUMAN
Uniprot Description
TGFBRAP1: Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2. Belongs to the TRAP1 family.
Chromosomal Location of Human Ortholog: 2q12.1
Cellular Component: membrane; cytoplasm
Molecular Function: protein binding; SMAD binding; transforming growth factor beta receptor binding
Biological Process: vesicle-mediated transport; intracellular protein transport; regulation of transcription, DNA-dependent; regulation of catalytic activity; transforming growth factor beta receptor signaling pathway; signal transduction
Research Articles on TGFBRAP1
Similar Products
Product Notes
The TGFBRAP1 tgfbrap1 (Catalog #AAA9213442) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 499-528. The TGFBRAP1 Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TGFBRAP1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry-paraffin (IHC-p). WB~~1:1000 IHC-P~~1:10~50. Researchers should empirically determine the suitability of the TGFBRAP1 tgfbrap1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TGFBRAP1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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