Western Blot (WB)
(STAM2 Antibody (Center) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the STAM2 antibody detected the STAM2 protein (arrow).)
Rabbit anti-Human STAM2 Polyclonal Antibody | anti-STAM2 antibody
STAM2 Antibody (Center)
Western Blot (WB)
(STAM2 Antibody (Center) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the STAM2 antibody detected the STAM2 protein (arrow).)
Western Blot (WB)
(STAM2 Antibody (Center) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the STAM2 antibody detected the STAM2 protein (arrow).)
STAM, an adaptor protein involved in the downstream signaling of
cytokine receptors, both of which contain a SH3 domain and the
immunoreceptor tyrosine-based activation motif (ITAM). Similar to
STAM, this protein acts downstream of JAK kinases, and is
phosphorylated in response to cytokine stimulation. This protein
and STAM thus are thought to exhibit compensatory effects on the
signaling pathway downstream of JAK kinases upon cytokine
stimulation.
Rismanchi, N., et al. Traffic 10(2):201-217(2009)
Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)
Kong, C., et al. J. Biol. Chem. 282(20):15294-15301(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation. [provided by RefSeq, Jul 2008]
Uniprot Description
STAM2: an adaptor protein involved in the downstream signaling of cytokine receptors. Contain a SH3 domain and immunoreceptor tyrosine-based activation motif (ITAM). Acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. May modulate the signaling pathway downstream of JAK kinases upon cytokine stimulation.
Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 2q23.3
Cellular Component: nucleoplasm; intracellular membrane-bound organelle; early endosome membrane; cytoplasm; cytosol
Molecular Function: protein binding
Biological Process: epidermal growth factor receptor signaling pathway; negative regulation of epidermal growth factor receptor signaling pathway; intracellular protein transport; endosome transport
Research Articles on STAM2
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Product Notes
The STAM2 stam2 (Catalog #AAA9210668) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 143-172. The STAM2 Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's STAM2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the STAM2 stam2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "STAM2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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