Western Blot (WB)
(RC3H1 Antibody (C-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the RC3H1 antibody detected the RC3H1 protein (arrow).)
Rabbit RC3H1 Polyclonal Antibody | anti-RC3H1 antibody
RC3H1 Antibody (C-term)
Western Blot (WB)
(RC3H1 Antibody (C-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the RC3H1 antibody detected the RC3H1 protein (arrow).)
Western Blot (WB)
(RC3H1 Antibody (C-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the RC3H1 antibody detected the RC3H1 protein (arrow).)
Immunohistochemistry (IHC)
(RC3H1 Antibody (C-term) (MBS9209134)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of RC3H1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(RC3H1 Antibody (C-term) (MBS9209134)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of RC3H1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
RING type ubiquitin ligase protein family (Vinuesa et al., 2005
[PubMed 15917799]). The roquin protein is distinguished by the
presence of a CCCH zinc finger found in RNA-binding proteins, and
localization to cytosolic RNA granules implicated in regulating
mRNA translation and stability.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein containing RING-type and C3H1-type zinc finger motifs. The encoded protein recognizes and binds to a constitutive decay element (CDE) in the 3' UTR of mRNAs, leading to mRNA deadenylation and degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Uniprot Description
RC3H1: Represses ICOS function, an essential costimulatory receptor for follicular T-cells. May act as an ubiquitin ligase that regulates ubiquitin-dependent control of AU-rich mRNAs by AUF1/HNRPD and HUR/ELAVL1. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin conjugating system; RNA-binding
Chromosomal Location of Human Ortholog: 1q25.1
Cellular Component: stress granule
Molecular Function: mRNA 3'-UTR binding; zinc ion binding
Biological Process: spleen development; negative regulation of germinal center formation; negative regulation of activated T cell proliferation; protein ubiquitination; negative regulation of B cell proliferation; regulation of mRNA stability; lymph node development; regulation of germinal center formation; T cell proliferation; negative regulation of T-helper cell differentiation; B cell homeostasis; regulation of T cell receptor signaling pathway; T cell homeostasis; cytoplasmic mRNA processing body assembly
Research Articles on RC3H1
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Product Notes
The RC3H1 rc3h1 (Catalog #AAA9209134) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1015-1043. The RC3H1 Antibody (C-term) reacts with Human (Predicted Reactivity: Mouse, Xenopus) and may cross-react with other species as described in the data sheet. AAA Biotech's RC3H1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the RC3H1 rc3h1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RC3H1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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