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Western Blot (WB) (Western blot analysis of extracts from HeLa cells, using CDC7 antibody.)

Rabbit CDC7 Polyclonal Antibody | anti-CDC7 antibody

Anti-CDC7 Rabbit pAb

Gene Names
CDC7; Hsk1; CDC7L1; HsCDC7; huCDC7
Reactivity
Human, Mouse, Rat
Applications
Western Blot, Flow Cytometry, Functional Assay
Purity
Affinity Chromatography
Synonyms
CDC7; Polyclonal Antibody; Anti-CDC7 Rabbit pAb; Cell division cycle 7-related protein kinase; EC 2.7.11.1; CDC7-related kinase; HsCdc7; huCdc7; CDC7L1; Hsk1; CDC7 kinase; anti-CDC7 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
CDC7 Antibody detects endogenous levels of total CDC7
Purity/Purification
Affinity Chromatography
Form/Format
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Sequence Length
574
Applicable Applications for anti-CDC7 antibody
Western Blot (WB), Flow Cytometry (FC/FACS)
Application Notes
WB: 1:1000-1:2000
FC/FACS: 1:100
Immunogen
A synthesized peptide derived from human CDC7
Subcellular Location
Nucleus
Preparation and Storage
Store at 4 degree C for short term.
Store at-20 degree C for long term.
Avoid freeze/thaw cycle.

Western Blot (WB)

(Western blot analysis of extracts from HeLa cells, using CDC7 antibody.)

Western Blot (WB) (Western blot analysis of extracts from HeLa cells, using CDC7 antibody.)
Related Product Information for anti-CDC7 antibody
DNA replication in eukaryotic cells is dependent on the phosphorylation of the pre-replicative complex (preRC) at the origin of replication. Two complexes of proteins mediate this event, the cyclin dependent kinase (CDK) complex, and the Cdc7 kinase-ASK complex. Human Cdc7 kinase consists of 574 amino acids with a molecular weight of 55 kDa. The activity of Cdc7 kinase oscillates during cell cycle. The major targets of Cdc7 kinase are proteins that belong to the MCM complex (mini chromosome maintenance proteins).

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
70kDa
NCBI Official Full Name
cell division cycle 7-related protein kinase
NCBI Official Synonym Full Names
cell division cycle 7
NCBI Official Symbol
CDC7
NCBI Official Synonym Symbols
Hsk1; CDC7L1; HsCDC7; huCDC7
NCBI Protein Information
cell division cycle 7-related protein kinase
UniProt Protein Name
Cell division cycle 7-related protein kinase
UniProt Gene Name
CDC7
UniProt Synonym Gene Names
CDC7L1; CDC7-related kinase; HsCdc7; huCdc7

NCBI Description

This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected. [provided by RefSeq, Aug 2008]

Uniprot Description

Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3.

Research Articles on CDC7

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Product Notes

The CDC7 cdc7 (Catalog #AAA477963) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-CDC7 Rabbit pAb reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CDC7 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Flow Cytometry (FC/FACS). WB: 1:1000-1:2000 FC/FACS: 1:100. Researchers should empirically determine the suitability of the CDC7 cdc7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CDC7, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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