Immunohistochemistry (IHC)
(FBXL15 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the FBXL15 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Rabbit FBXL15 Polyclonal Antibody | anti-FBXL15 antibody
FBXL15 Antibody (C-term)
WB~~1:1000
Immunohistochemistry (IHC)
(FBXL15 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the FBXL15 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(FBXL15 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the FBXL15 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Western Blot (WB)
(Western blot analysis of FBXL15 Antibody (C-term) (RB26324) in MDA-MB435 cell line lysates (35ug/lane).FBXL15 (arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of FBXL15 Antibody (C-term) (RB26324) in MDA-MB435 cell line lysates (35ug/lane).FBXL15 (arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of FBXL15 Antibody (C-term) in mouse kidney tissue lysates (35ug/lane).FBXL15 (arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of FBXL15 Antibody (C-term) in mouse kidney tissue lysates (35ug/lane).FBXL15 (arrow) was detected using the purified Pab.)
NCBI and Uniprot Product Information
Uniprot Description
FBXL15: Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2. Belongs to the FBXL15 family.
Chromosomal Location of Human Ortholog: 10q24.32
Cellular Component: cytoplasm; SCF ubiquitin ligase complex
Molecular Function: protein binding; ubiquitin-protein ligase activity
Biological Process: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; dorsal/ventral pattern formation; protein ubiquitination; G2/M transition of mitotic cell cycle; positive regulation of BMP signaling pathway; bone mineralization
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Product Notes
The FBXL15 fbxl15 (Catalog #AAA9208241) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 252-280. The FBXL15 Antibody (C-term) reacts with Human (Predicted Reactivity: Bovine, Mouse, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's FBXL15 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). IHC~~1:50~100 WB~~1:1000. Researchers should empirically determine the suitability of the FBXL15 fbxl15 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FBXL15, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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