Western Blot (WB)
(SOS2 Antibody (N-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the SOS2 antibody detected the SOS2 protein (arrow).)
Rabbit SOS2 Polyclonal Antibody | anti-SOS2 antibody
SOS2 Antibody (N-term)
Reactivity
Human (Predicted Reactivity: Mouse)
Applications
Flow Cytometry, Functional Assay, ELISA, Western Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
SOS2; Polyclonal Antibody; SOS2 Antibody (N-term); Son of sevenless homolog 2; SOS-2; anti-SOS2 antibody
Host
Rabbit
Reactivity
Human (Predicted Reactivity: Mouse)
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This SOS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 188-215 amino acids from the N-terminal region of human SOS2.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (varies by lot)
Sequence Positions
188-215
Sequence Length
1332
Applicable Applications for anti-SOS2 antibody
Flow Cytometry (FC/FACS), ELISA (EIA), Western Blot (WB)
Application Notes
WB~~1:1000
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Western Blot (WB)
(SOS2 Antibody (N-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the SOS2 antibody detected the SOS2 protein (arrow).)
Western Blot (WB)
(SOS2 Antibody (N-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the SOS2 antibody detected the SOS2 protein (arrow).)
Flow Cytometry (FC/FACS)
(SOS2 Antibody (N-term) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Flow Cytometry (FC/FACS)
(SOS2 Antibody (N-term) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Related Product Information for anti-SOS2 antibody
SOS2 promotes the exchange of Ras-bound GDP by GTP (By similarity).
Product Categories/Family for anti-SOS2 antibody
References
Takefuji, M., et al. J. Hum. Genet. 55(1):42-49(2010)
Kurada, B.R., et al. J. Biol. Chem. 284(20):13533-13541(2009)
Hamilton, G., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B (4), 508-516 (2007) :
Wu, C., et al. Proteomics 7(11):1775-1785(2007)
Roberts, A.E., et al. Nat. Genet. 39(1):70-74(2007)
Kurada, B.R., et al. J. Biol. Chem. 284(20):13533-13541(2009)
Hamilton, G., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B (4), 508-516 (2007) :
Wu, C., et al. Proteomics 7(11):1775-1785(2007)
Roberts, A.E., et al. Nat. Genet. 39(1):70-74(2007)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
152979
NCBI Official Full Name
son of sevenless homolog 2
NCBI Official Synonym Full Names
son of sevenless homolog 2 (Drosophila)
NCBI Official Symbol
SOS2
NCBI Protein Information
son of sevenless homolog 2
UniProt Protein Name
Son of sevenless homolog 2
Protein Family
UniProt Gene Name
SOS2
UniProt Synonym Gene Names
SOS-2
UniProt Entry Name
SOS2_HUMAN
Uniprot Description
SOS2: a guanine nucleotide exchange factor that activates Ras by catalyzing the exchange of bound GDP for GTP. Interacts with GRB2.
Protein type: GEFs; Adaptor/scaffold; Motility/polarity/chemotaxis; GEFs, Ras
Chromosomal Location of Human Ortholog: 14q21
Cellular Component: cytosol
Molecular Function: protein binding; Rho guanyl-nucleotide exchange factor activity; DNA binding; protein heterodimerization activity
Biological Process: positive regulation of small GTPase mediated signal transduction; axon guidance; regulation of small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; small GTPase mediated signal transduction
Research Articles on SOS2
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Product Notes
The SOS2 sos2 (Catalog #AAA9206707) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 188-215. The SOS2 Antibody (N-term) reacts with Human (Predicted Reactivity: Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's SOS2 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS), ELISA (EIA), Western Blot (WB). WB~~1:1000. Researchers should empirically determine the suitability of the SOS2 sos2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SOS2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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