Rabbit DVL2 Polyclonal Antibody | anti-DVL2 antibody

DVL2 Antibody (C-term)

Cat. Num. AAA9206378

• Reactivity: Human (Predicted Reactivity: Mouse)
• Applications: Western Blot, ELISA
• Purity: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Synonyms: DVL2; Polyclonal Antibody; DVL2 Antibody (C-term); Segment polarity protein dishevelled homolog DVL-2; Dishevelled-2; DSH homolog 2; anti-DVL2 antibody

• Host: Rabbit
• Reactivity: Human (Predicted Reactivity: Mouse)
• Clonality: Polyclonal
• Isotype: Rabbit Ig
• Specificity: This DVL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 588-617 amino acids from the C-terminal region of human DVL2.
• Purity/Purification: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Concentration: Vial Concentration: 0.5 (varies by lot)
• Sequence Positions: 588-617
• Sequence Length: 736

• Applicable Applications for anti-DVL2 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB~~1:1000
• Antigen Type: Synthetic Peptide
• Antigen Source: HUMAN
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(DVL2 Antibody (C-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the DVL2 antibody detected the DVL2 protein (arrow).)

Related Product Information for anti-DVL2 antibody

This gene encodes a member of the dishevelled (dsh)
protein family. The vertebrate dsh proteins have approximately 40%
amino acid sequence similarity with Drosophila dsh. This gene
encodes a 90-kD protein that undergoes posttranslational
phosphorylation to form a 95-kD cytoplasmic protein, which may play
a role in the signal transduction pathway mediated by multiple Wnt
proteins. The mechanisms of dishevelled function in Wnt signaling
are likely to be conserved among metazoans.

Product Categories/Family for anti-DVL2 antibody

Signal Transduction

References

Inkster, B., et al. Neuroimage 53(3):908-917(2010)
Kikuchi, K., et al. EMBO J. 29(20):3470-3483(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Gao, C., et al. Nat. Cell Biol. 12(8):781-790(2010)
Gnad, T., et al. Mol. Cancer 9, 31 (2010) :

NCBI and Uniprot Product Information

• NCBI GI #: 4758216
• NCBI GeneID: 1856
• NCBI Accession #: NP_004413.1
• NCBI GenBank Nucleotide #: NM_004422.2
• UniProt Accession #: O14641; Q53XM0; D3DTN3
• Molecular Weight: 78948
• NCBI Official Full Name: segment polarity protein dishevelled homolog DVL-2
• NCBI Official Synonym Full Names: dishevelled segment polarity protein 2
• NCBI Official Symbol: DVL2
• NCBI Protein Information: segment polarity protein dishevelled homolog DVL-2
• UniProt Protein Name: Segment polarity protein dishevelled homolog DVL-2
• Protein Family: Segment polarity protein dishevelled
• UniProt Gene Name: DVL2
• UniProt Synonym Gene Names: Dishevelled-2
• UniProt Entry Name: DVL2_HUMAN

NCBI Description

This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008]

Uniprot Description

DVL2: a protein in the WNT/planar cell polarity (PCP) signaling pathway. Dvl2-deficient mice indicate that Dvl2 is essential for normal cardiac morphogenesis, somite segmentation and neural tube closure. Transduces the Wnt signal by interacting with the cytoplasmic Axin complex. Dvl and Axin each contain a DIX domains, which mediate their dynamic polymerization. The Dvl-Axin interaction is essential for Wnt signaling. Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2. Interacts with Dixin and Rac. There is functional redundancy between Dvl1 and Dvl2 in some phenotypes.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: apical part of cell; cytoplasm; plasma membrane; clathrin-coated endocytic vesicle; cytoplasmic vesicle; nucleus; cytosol

Molecular Function: identical protein binding; protein domain specific binding; protein binding; protein self-association; frizzled binding

Biological Process: transcription from RNA polymerase II promoter; segment specification; positive regulation of JNK activity; Wnt receptor signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway; convergent extension involved in neural plate elongation; positive regulation of transcription, DNA-dependent; heart development; neural tube closure; positive regulation of transcription factor activity; Wnt receptor signaling pathway through beta-catenin; positive regulation of protein amino acid phosphorylation