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Western Blot (WB) (All lanes : Anti-CLEC16A Antibody (C-term) at 1:1000 dilutionLane 1: T47D whole cell lysatesLane 2: mouse heart lysatesLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilutionPredicted band size : 118 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)

Rabbit anti-Human, mouse CLEC16A Polyclonal Antibody | anti-CLEC16A antibody

CLEC16A Antibody (C-term)

Gene Names
CLEC16A; Gop-1; KIAA0350
Reactivity
Human, mouse
Applications
Western Blot, ELISA
Purity
Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
CLEC16A; Polyclonal Antibody; CLEC16A Antibody (C-term); Protein CLEC16A; C-type lectin domain family 16 member A {ECO:0000312|HGNC:HGNC:29013}; CLEC16A HGNC:29013); KIAA0350; anti-CLEC16A antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, mouse
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This CLEC16A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 773-805 amino acids from the C-terminal region of human CLEC16A.
Purity/Purification
Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (varies by lot)
Sequence Length
906
Applicable Applications for anti-CLEC16A antibody
Western Blot (WB), ELISA (EIA)
Application Notes
WB~~1:1000
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(All lanes : Anti-CLEC16A Antibody (C-term) at 1:1000 dilutionLane 1: T47D whole cell lysatesLane 2: mouse heart lysatesLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilutionPredicted band size : 118 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)

Western Blot (WB) (All lanes : Anti-CLEC16A Antibody (C-term) at 1:1000 dilutionLane 1: T47D whole cell lysatesLane 2: mouse heart lysatesLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilutionPredicted band size : 118 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)
Related Product Information for anti-CLEC16A antibody
Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PARK2 pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PARK2 pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteosomal degradation, RNF41/NRDP1 which regulates proteosomal degradation of PARK2. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health.
References
Nagase T.,et al.DNA Res. 4:141-150(1997).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hakonarson H.,et al.Nature 448:591-594(2007).
Soleimanpour S.A.,et al.Cell 157:1577-1590(2014).

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
117715
NCBI Official Full Name
protein CLEC16A isoform 2
NCBI Official Synonym Full Names
C-type lectin domain family 16, member A
NCBI Official Symbol
CLEC16A
NCBI Official Synonym Symbols
Gop-1; KIAA0350
NCBI Protein Information
protein CLEC16A
UniProt Protein Name
Protein CLEC16A
Protein Family
UniProt Gene Name
CLEC16A
UniProt Entry Name
CL16A_HUMAN

NCBI Description

This gene encodes a member of the C-type lectin domain containing family. Single nucleotide polymorphisms in introns of this gene have been associated with diabetes mellitus, multiple sclerosis and rheumatoid arthritis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Uniprot Description

CLEC16A: Insulin-dependent diabetes mellitus is significantly associated with variation within a 233-kb linkage disequilibrium block on chromosome 16p13 that includes KIAA0350. Three common non-coding variants of KIAA0350 in strong linkage disequilibrium reach genome-wide significance for association with the disease (PubMed:17632545). Belongs to the CLEC16A/gop-1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 16p13.13

Cellular Component: lysosomal membrane; endosome membrane

Biological Process: autophagy

Research Articles on CLEC16A

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Product Notes

The CLEC16A clec16a (Catalog #AAA9205425) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CLEC16A Antibody (C-term) reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CLEC16A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the CLEC16A clec16a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CLEC16A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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