Western Blot (WB)
(ITM2C Antibody (N-term) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the ITM2C antibody detected the ITM2C protein (arrow).)
Rabbit ITM2C Polyclonal Antibody | anti-ITM2C antibody
ITM2C Antibody (N-term)
Gene Names
ITM2C; E25; BRI3; E25C; ITM3; BRICD2C
Reactivity
Human (Predicted Reactivity: Monkey)
Applications
Western Blot, ELISA
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
ITM2C; Polyclonal Antibody; ITM2C Antibody (N-term); Integral membrane protein 2C; Cerebral protein 14; Transmembrane protein BRI3; CT-BRI3; BRI3; anti-ITM2C antibody
Host
Rabbit
Reactivity
Human (Predicted Reactivity: Monkey)
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This ITM2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 27-55 amino acids from the N-terminal region of human ITM2C.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.36 (varies by lot)
Sequence Positions
27-55
Sequence Length
220
Applicable Applications for anti-ITM2C antibody
Western Blot (WB), ELISA (EIA)
Application Notes
WB~~1:1000
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Western Blot (WB)
(ITM2C Antibody (N-term) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the ITM2C antibody detected the ITM2C protein (arrow).)
Western Blot (WB)
(ITM2C Antibody (N-term) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the ITM2C antibody detected the ITM2C protein (arrow).)
Related Product Information for anti-ITM2C antibody
Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha-and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity).
Product Categories/Family for anti-ITM2C antibody
References
Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)
Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)
Matsuda, S., et al. J. Biol. Chem. 284(23):15815-15825(2009)
Matsuda, S., et al. Mol Neurodegener 4, 41 (2009) :
Gong, Y., et al. BMB Rep 41(4):287-293(2008)
Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)
Matsuda, S., et al. J. Biol. Chem. 284(23):15815-15825(2009)
Matsuda, S., et al. Mol Neurodegener 4, 41 (2009) :
Gong, Y., et al. BMB Rep 41(4):287-293(2008)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
30224
NCBI Official Full Name
integral membrane protein 2C isoform 3
NCBI Official Synonym Full Names
integral membrane protein 2C
NCBI Official Symbol
ITM2C
NCBI Official Synonym Symbols
E25; BRI3; E25C; ITM3; BRICD2C
NCBI Protein Information
integral membrane protein 2C
UniProt Protein Name
Integral membrane protein 2C
Protein Family
UniProt Gene Name
ITM2C
UniProt Synonym Gene Names
BRI3
UniProt Entry Name
ITM2C_HUMAN
Uniprot Description
ITM2C: Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C- terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation. Belongs to the ITM2 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 2q37
Cellular Component: Golgi apparatus; lysosomal membrane; perinuclear region of cytoplasm; lysosome; integral to membrane; plasma membrane
Molecular Function: protein binding; beta-amyloid binding; ATP binding
Biological Process: neuron differentiation
Research Articles on ITM2C
Similar Products
Product Notes
The ITM2C itm2c (Catalog #AAA9201371) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 27-55. The ITM2C Antibody (N-term) reacts with Human (Predicted Reactivity: Monkey) and may cross-react with other species as described in the data sheet. AAA Biotech's ITM2C can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the ITM2C itm2c for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ITM2C, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
