Rabbit PLA2G7 Polyclonal Antibody | anti-PLA2G7 antibody

PLA2G7 Polyclonal Antibody

Cat. Num. AAA9129643

• Gene Names: PLA2G7; PAFAD; PAFAH; LP-PLA2; LDL-PLA2
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry
• Purity: Affinity purification
• Synonyms: PLA2G7; Polyclonal Antibody; PLA2G7 Polyclonal Antibody ; anti-PLA2G7 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purification
• Sequence Length: 441

• Applicable Applications for anti-PLA2G7 antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50 - 1:100
• Immunogen: Recombinant protein of human PLA2G7
• Preparation and Storage: Store at -20 degree C. Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human prostate using PLA2G7 antibody at dilution of 1:100 (40x lens).)

Product Categories/Family for anti-PLA2G7 antibody

Polyclonal

NCBI and Uniprot Product Information

• NCBI GI #: 270133071
• NCBI GeneID: 7941
• NCBI Accession #: NP_001161829.1
• NCBI GenBank Nucleotide #: NM_001168357.1
• UniProt Accession #: Q13093; Q15692; Q5VTT1; Q8IVA2; A5HTT5
• Molecular Weight: Calculated MW: 50kDa; Molecular Weight: 441
• NCBI Official Full Name: platelet-activating factor acetylhydrolase
• NCBI Official Synonym Full Names: phospholipase A2 group VII
• NCBI Official Symbol: PLA2G7
• NCBI Official Synonym Symbols: PAFAD; PAFAH; LP-PLA2; LDL-PLA2
• NCBI Protein Information: platelet-activating factor acetylhydrolase
• UniProt Protein Name: Platelet-activating factor acetylhydrolase
• Protein Family: Platelet-activating factor acetylhydrolase
• UniProt Gene Name: PLA2G7
• UniProt Synonym Gene Names: PAFAH; PAF acetylhydrolase; gVIIA-PLA2; LDL-PLA(2)
• UniProt Entry Name: PAFA_HUMAN

NCBI Description

The protein encoded by this gene is a secreted enzyme that catalyzes the degradation of platelet-activating factor to biologically inactive products. Defects in this gene are a cause of platelet-activating factor acetylhydrolase deficiency. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2009]

Uniprot Description

PLA2G7: Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids. Defects in PLA2G7 are the cause of platelet-activating factor acetylhydrolase deficiency (PAFAD). An enzymatic deficiency that results in exacerbated bodily response to inflammatory agents. Asthmatic individuals affected by this condition may manifest severe respiratory symptoms. Defects in PLA2G7 are a cause of susceptibility to asthma (ASTHMA). The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with weezing due to spasmodic contraction of the bronchi. PLA2G7 variants can be a risk factor for the development of asthma and PLA2G7 may act as a modifier gene that modulates the severity of this disease. Defects in PLA2G7 are a cause of susceptibility to atopic hypersensitivity (ATOPY). A condition characterized by predisposition to develop hypersensitivity reactions. Atopic individuals can develop eczema, allergic rhinitis and allergic asthma. Belongs to the AB hydrolase superfamily. Lipase family.

Protein type: EC 3.1.1.47; Lipid Metabolism - ether lipid; Secreted; Secreted, signal peptide; Hydrolase

Chromosomal Location of Human Ortholog: 6p21.2-p12

Cellular Component: cytoplasm; extracellular region

Molecular Function: 1-alkyl-2-acetylglycerophosphocholine esterase activity; calcium-independent phospholipase A2 activity; phospholipid binding

Biological Process: cellular protein metabolic process; lipid catabolic process; positive regulation of inflammatory response

Disease: Asthma, Susceptibility To; Ige Responsiveness, Atopic; Platelet-activating Factor Acetylhydrolase Deficiency