Collagen alpha-2 (IV) chain (COL4A2) Recombinant Protein | COL4A2 recombinant protein

Recombinant Human Collagen alpha-2 (IV) chain (COL4A2), partial

Cat. Num. AAA9018436

• Gene Names: COL4A2; ICH; POREN2
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Collagen alpha-2 (IV) chain (COL4A2); Recombinant Human Collagen alpha-2 (IV) chain (COL4A2); partial; COL4A2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1261-1712aa, Partial
• Sequence: SPGLQGFPGITPPSNISGAPGDKGAPGIFGLKGYRGPPGPPGSAALPGSKGDTGNPGAPGTPGTKGWAGDSGPQGRPGVFGLPGEKGPRGEQGFMGNTGPTGAVGDRGPKGPKGDPGFPGAPGTVGAPGIAGIPQKIAVQPGTVGPQGRRGPPGAPGEMGPQGPPGEPGFRGAPGKAGPQGRGGVSAVPGFRGDEGPIGHQGPIGQEGAPGRPGSPGLPGMPGRSVSIGYLLVKHSQTDQEPMCPVGMNKLWSGYSLLYFEGQEKAHNQDLGLAGSCLARFSTMPFLYCNPGDVCYYASRNDKSYWLSTTAPLPMMPVAEDEIKPYISRCSVCEAPAIAIAVHSQDVSIPHCPAGWRSLWIGYSFLMHTAAGDEGGGQSLVSPGSCLEDFRATPFIECNGGRGTCHYYANKYSFWLTTIPEQSFQGSPSADTLKAGLIRTHISRCQVCMKNL

• Species: Homo sapiens (Human)
• Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20 degree C/-80 degree C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
• Preparation and Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Product Categories/Family for COL4A2 recombinant protein

Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 116256354
• NCBI GeneID: 1284
• NCBI Accession #: NP_001837.2
• NCBI GenBank Nucleotide #: NM_001846.2
• UniProt Accession #: P08572; Q14052; Q548C3; Q5VZA9; Q66K23
• Molecular Weight: 167,553 Da
• NCBI Official Full Name: collagen alpha-2(IV) chain preproprotein
• NCBI Official Synonym Full Names: collagen, type IV, alpha 2
• NCBI Official Symbol: COL4A2
• NCBI Official Synonym Symbols: ICH; POREN2
• NCBI Protein Information: collagen alpha-2(IV) chain; collagen alpha-2(IV) chain; canstatin
• UniProt Protein Name: Collagen alpha-2(IV) chain
• Protein Family: Collagen
• UniProt Gene Name: COL4A2
• UniProt Entry Name: CO4A2_HUMAN

NCBI Description

This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of the protein, known as canstatin, is an inhibitor of angiogenesis and tumor growth. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. [provided by RefSeq, Jul 2008]

Uniprot Description

COL4A2: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Defects in COL4A2 are the cause of porencephaly type 2 (POREN2). POREN2 is a neurologic disorder characterized by a fluid-filled cysts or cavities within the cerebral hemispheres. Affected individuals typically have hemiplegia, seizures, and intellectual disability. Porencephaly type 2, or schizencephalic porencephaly, is usually symmetric and represents a primary defect in the development of the cerebral ventricles. Defects in COL4A2 are a cause of susceptibility to intracerebral hemorrhage (ICH). ICH is a pathological condition characterized by bleeding into one or both cerebral hemispheres including the basal ganglia and the cerebral cortex. It is often associated with hypertension and craniocerebral trauma. Intracerebral bleeding is a common cause of stroke. Belongs to the type IV collagen family.

Protein type: Secreted; Extracellular matrix; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 13q34

Cellular Component: extracellular matrix; intracellular membrane-bound organelle; endoplasmic reticulum lumen; collagen type IV; extracellular region

Molecular Function: protein binding; extracellular matrix structural constituent

Biological Process: axon guidance; collagen catabolic process; extracellular matrix disassembly; receptor-mediated endocytosis; negative regulation of angiogenesis; extracellular matrix organization and biogenesis; transcription, DNA-dependent; angiogenesis

Disease: Porencephaly 2; Hemorrhage, Intracerebral, Susceptibility To