Rabbit TCIRG1 Polyclonal Antibody | anti-TCIRG1 antibody

TCIRG1 Polyclonal Antibody

Cat. Num. AAA8570064

• Gene Names: TCIRG1; a3; Stv1; Vph1; Atp6i; OC116; OPTB1; TIRC7; ATP6N1C; ATP6V0A3; OC-116kDa
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Affinity Purification
• Synonyms: TCIRG1; Polyclonal Antibody; TCIRG1 Polyclonal Antibody; anti-TCIRG1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Form/Format: PBS with 0.02% sodium azide, 50% glycerol, pH 7.3.
• Sequence Length: 830

• Applicable Applications for anti-TCIRG1 antibody: Western Blot (WB)
• Application Notes: WB: 1:200-1:2000
• Immunogen: Recombinant protein of human TCIRG1 (NP_006010.2).
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Related Product Information for anti-TCIRG1 antibody

This gene encodes a subunit of a large protein complex known as a vacuolar H+-ATPase (V-ATPase). The protein complex acts as a pump to move protons across the membrane. This movement of protons helps regulate the pH of cells and their surrounding environment. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. V-ATPase is comprised of a cytosolic V1 domain and a transmembrane V0 domain. Alternative splicing results in multiple transcript variants. Mutations in this gene are associated with infantile malignant osteopetrosis.

NCBI and Uniprot Product Information

• NCBI GI #: 19924145
• NCBI GeneID: 10312
• NCBI Accession #: NP_006010
• NCBI GenBank Nucleotide #: NP_006010.2
• UniProt Accession #: Q13488
• Molecular Weight: 68kDa; 92kDa
• NCBI Official Full Name: V-type proton ATPase 116 kDa subunit a isoform 3 isoform a
• NCBI Official Synonym Full Names: T cell immune regulator 1, ATPase H+ transporting V0 subunit a3
• NCBI Official Symbol: TCIRG1
• NCBI Official Synonym Symbols: a3; Stv1; Vph1; Atp6i; OC116; OPTB1; TIRC7; ATP6N1C; ATP6V0A3; OC-116kDa
• NCBI Protein Information: V-type proton ATPase 116 kDa subunit a isoform 3; V-type proton ATPase 116 kDa subunit a
• UniProt Protein Name: V-type proton ATPase 116 kDa subunit a isoform 3
• Protein Family: V-type proton ATPase
• UniProt Gene Name: TCIRG1
• UniProt Synonym Gene Names: ATP6N1C; ATP6V0A3; V-ATPase 116 kDa isoform a3; OC-116 kDa; OC116; TIRC7
• UniProt Entry Name: VPP3_HUMAN

NCBI Description

This gene encodes a subunit of a large protein complex known as a vacuolar H+-ATPase (V-ATPase). The protein complex acts as a pump to move protons across the membrane. This movement of protons helps regulate the pH of cells and their surrounding environment. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. V-ATPase is comprised of a cytosolic V1 domain and a transmembrane V0 domain. Alternative splicing results in multiple transcript variants. Mutations in this gene are associated with infantile malignant osteopetrosis. [provided by RefSeq, May 2017]

Uniprot Description

TCIRG1: Part of the proton channel of V-ATPases. Seems to be directly involved in T-cell activation. Defects in TCIRG1 are the cause of osteopetrosis autosomal recessive type 1 (OPTB1); also called autosomal recessive Albers-Schonberg disease or infantile malignant osteopetrosis. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. The features of OPTB1 are macrocephaly, progressive deafness and blindness, hepatosplenomegaly, and severe anemia beginning in early infancy or in fetal life. Deafness and blindness are generally thought to represent effects of pressure on nerves. Belongs to the V-ATPase 116 kDa subunit family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter, iron; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Transporter; Transporter, ion channel; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q13.2

Cellular Component: phagocytic vesicle membrane; mitochondrion; integral to plasma membrane; lysosomal membrane; apical plasma membrane; plasma membrane; endosome membrane; vacuolar proton-transporting V-type ATPase complex

Molecular Function: transporter activity; hydrogen ion transporting ATPase activity, rotational mechanism; ATPase binding

Biological Process: interaction with host; vacuolar acidification; proton transport; ATP synthesis coupled proton transport; cellular iron ion homeostasis; ATP hydrolysis coupled proton transport; positive regulation of cell proliferation; insulin receptor signaling pathway; cellular defense response; transferrin transport; transmembrane transport

Disease: Osteopetrosis, Autosomal Recessive 1