Rabbit anti-Human, Mouse KDM5A Polyclonal Antibody | anti-KDM5A antibody
KDM5A Rabbit pAb
ICC/IF: 1:100-1:500
IP: 1:80
FC/FACS: 1:200
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the Jumonji, AT-rich interactive domain 1 (JARID1) histone demethylase protein family. The encoded protein plays a role in gene regulation through the histone code by specifically demethylating lysine 4 of histone H3. The encoded protein interacts with many other proteins, including retinoblastoma protein, and is implicated in the transcriptional regulation of Hox genes and cytokines. This gene may play a role in tumor progression. [provided by RefSeq, Aug 2013]
Uniprot Description
Function: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May stimulate transcription mediated by nuclear receptors. May be involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Ref.8 Ref.9 Ref.11 Ref.12 Ref.13
Cofactor: Binds 1 Fe2+ ion per subunit
By similarity.
Subunit structure: Interacts with SUZ12; the interaction is direct
By similarity. Interacts with the viral protein-binding domain of RB1. Interacts with ESR1, MYC, MYCN and LMO2. Ref.1 Ref.6 Ref.7 Ref.8 Ref.9 Ref.14
Subcellular location: Nucleus › nucleolus. Note: Occupies promoters of genes involved in RNA metabolism and mitochondrial function
By similarity. Ref.6 Ref.9
Domain: The GSGFP motif is required for the interaction with SUZ12
By similarity.
Sequence similarities: Belongs to the JARID1 histone demethylase family.Contains 1 ARID domain.Contains 1 JmjC domain.Contains 1 JmjN domain.Contains 3 PHD-type zinc fingers.
Sequence caution: The sequence AAB28544.1 differs from that shown. Reason: Frameshift at several positions. The sequence BAE06081.1 differs from that shown. Reason: Erroneous initiation.
Research Articles on KDM5A
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Product Notes
The KDM5A kdm5a (Catalog #AAA8543800) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The KDM5A Rabbit pAb reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's KDM5A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Flow Cytometry (FC/FACS). WB: 1:500-1:2000 ICC/IF: 1:100-1:500 IP: 1:80 FC/FACS: 1:200. Researchers should empirically determine the suitability of the KDM5A kdm5a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KDM5A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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