Rabbit anti-Human VPP2 Polyclonal Antibody | anti-VPP2 antibody

VPP2 Polyclonal Antibody

Cat. Num. AAA8530870

• Gene Names: ATP6V0A2; A2; RTF; TJ6; WSS; ARCL; J6B7; STV1; TJ6M; TJ6S; VPH1; ARCL2A; ATP6A2; ATP6N1D
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: VPP2; Polyclonal Antibody; VPP2 Polyclonal Antibody; V-type proton ATPase 116 kDa subunit a isoform 2; V-ATPase 116 kDa isoform a2; Lysosomal H(+)-transporting ATPase V0 subunit a2; TJ6; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2; ATP6V0A2; anti-VPP2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
• Sequence Length: 856

• Applicable Applications for anti-VPP2 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:500-2000; ELISA: 1:5000-20000
• Preparation and Storage: Store at-20 degree C for 1 year.

NCBI and Uniprot Product Information

• NCBI GI #: 42741679
• NCBI GeneID: 23545
• NCBI Accession #: NP_036595.2
• NCBI GenBank Nucleotide #: NM_012463.3
• UniProt Accession #: Q9Y487; Q6NUM0; A8K026
• Molecular Weight: 94
• NCBI Official Full Name: V-type proton ATPase 116 kDa subunit a isoform 2
• NCBI Official Synonym Full Names: ATPase H+ transporting V0 subunit a2
• NCBI Official Symbol: ATP6V0A2
• NCBI Official Synonym Symbols: A2; RTF; TJ6; WSS; ARCL; J6B7; STV1; TJ6M; TJ6S; VPH1; ARCL2A; ATP6A2; ATP6N1D
• NCBI Protein Information: V-type proton ATPase 116 kDa subunit a isoform 2; V-type proton ATPase 116 kDa subunit a
• UniProt Protein Name: V-type proton ATPase 116 kDa subunit a isoform 2
• UniProt Gene Name: ATP6V0A2
• UniProt Synonym Gene Names: V-ATPase 116 kDa isoform a2

NCBI Description

The protein encoded by this gene is a subunit of the vacuolar ATPase (v-ATPase), an heteromultimeric enzyme that is present in intracellular vesicles and in the plasma membrane of specialized cells, and which is essential for the acidification of diverse cellular components. V-ATPase is comprised of a membrane peripheral V(1) domain for ATP hydrolysis, and an integral membrane V(0) domain for proton translocation. The subunit encoded by this gene is a component of the V(0) domain. Mutations in this gene are a cause of both cutis laxa type II and wrinkly skin syndrome. [provided by RefSeq, Jul 2009]

Uniprot Description

Part of the proton channel of V-ATPases. Essential component of the endosomal pH-sensing machinery. May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe2+ prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633).