Rabbit KOR-1 Polyclonal Antibody | anti-KOR-1 antibody

KOR-1 Antibody

Cat. Num. AAA8529259

• Gene Names: Oprk1; KOR; R21; KOR-1; MSL-1; Oprk2; K-OR-1
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Immunogen affinity purified
• Synonyms: KOR-1; Polyclonal Antibody; KOR-1 Antibody; K-OR-1; Kappa opioid receptor; Kappa type opioid receptor; Kappa-type opioid receptor; KOR 1; KOR; Opiate receptor kappa 1; Opiate receptor; kappa 1; Opioid receptor; OPRK 1; OPRK; OPRK_HUMAN; OPRK1; Oprk2; R21; anti-KOR-1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Immunogen affinity purified
• Sequence Length: 380

• Applicable Applications for anti-KOR-1 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: A synthesized peptide derived from human KOR-1
• Storage Buffer: Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

NCBI and Uniprot Product Information

• NCBI GI #: 324120905
• NCBI GeneID: 18387
• NCBI Accession #: NP_001191300.1
• NCBI GenBank Nucleotide #: NM_001204371.1
• UniProt Accession #: P33534
• Molecular Weight: 58kDa
• NCBI Official Full Name: kappa-type opioid receptor isoform 1
• NCBI Official Synonym Full Names: opioid receptor, kappa 1
• NCBI Official Symbol: Oprk1
• NCBI Official Synonym Symbols: KOR; R21; KOR-1; MSL-1; Oprk2; K-OR-1
• NCBI Protein Information: kappa-type opioid receptor
• UniProt Protein Name: Kappa-type opioid receptor
• UniProt Gene Name: Oprk1
• UniProt Synonym Gene Names: K-OR-1; KOR-1

NCBI Description

This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]

Uniprot Description

G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.