USP48 Antibody | anti-USP48 antibody

USP48 Antibody

Cat. Num. AAA8509964

• Gene Names: USP48; USP31; RAP1GA1
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: USP48; USP48 Antibody; Ubiquitin carboxyl-terminal hydrolase 48; EC 3.1.2.15; Ubiquitin thioesterase 48; Ubiquitin-specific-processing protease 48; Deubiquitinating enzyme 48; USP31; anti-USP48 antibody

• Reactivity: Human, Mouse, Rat
• Specificity: USP48 antibody detects endogenous levels of total USP48 protein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 485

• Applicable Applications for anti-USP48 antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:50-1:100; ELISA: 1:5000
• Immunogen: The antiserum was produced against synthesized peptide derived from internal of human USP48.
• Preparation and Storage: Store at-20 degree C for 1 year.

References

Lockhart P.J., DNA Seq. 15:9-14(2004). Gregory S.G., Nature 441:315-321(2006). Ota T., Nat. Genet. 36:40-45(2004).

NCBI and Uniprot Product Information

• NCBI GI #: 76257392
• NCBI GeneID: 84196
• NCBI Accession #: NP_001027902.1
• NCBI GenBank Nucleotide #: NM_001032730.2
• UniProt Accession #: Q86UV5; Q2M3I4; Q5SZI4; Q5T3T5; Q6NX53; Q8N3F6; Q96F64; Q96IQ3; Q9H5N3; Q9H5T7; Q9NUJ6; B7ZKS7
• Molecular Weight: 120,526 Da
• NCBI Official Full Name: ubiquitin carboxyl-terminal hydrolase 48 isoform b
• NCBI Official Synonym Full Names: ubiquitin specific peptidase 48
• NCBI Official Symbol: USP48
• NCBI Official Synonym Symbols: USP31; RAP1GA1
• NCBI Protein Information: ubiquitin carboxyl-terminal hydrolase 48
• UniProt Protein Name: Ubiquitin carboxyl-terminal hydrolase 48
• Protein Family: Ubiquitin carboxyl-terminal hydrolase
• UniProt Gene Name: USP48
• UniProt Synonym Gene Names: USP31

NCBI Description

This gene encodes a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Family members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin. Enzymes in peptidase family C19 are involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Uniprot Description

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. May be involved in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites.