Testing Data
(JARID1B (N-terminus) antibody at 1/2000 dilution interacts with recombinant i JARID1B protein with a GST tag. Predicted band size: 46KDa. Observed band size: 46KDa.)
anti-Human JARID1B Antibody | anti-JARID1B antibody
JARID1B Antibody
WB: 1:100-1:2000
Testing Data
(JARID1B (N-terminus) antibody at 1/2000 dilution interacts with recombinant i JARID1B protein with a GST tag. Predicted band size: 46KDa. Observed band size: 46KDa.)
Testing Data
(JARID1B (N-terminus) antibody at 1/2000 dilution interacts with recombinant i JARID1B protein with a GST tag. Predicted band size: 46KDa. Observed band size: 46KDa.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
Uniprot Description
Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:24952722, PubMed:27214403, PubMed:28262558). Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5 (PubMed:24952722). In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 ().
Research Articles on JARID1B
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Product Notes
The JARID1B kdm5b (Catalog #AAA850990) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The JARID1B Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's JARID1B can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). ELISA: 1:5000-1:20000 WB: 1:100-1:2000. Researchers should empirically determine the suitability of the JARID1B kdm5b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "JARID1B, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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