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Testing Data (Peptide-+)

APC1 Antibody | anti-APC1 antibody

APC1 Antibody

Gene Names
ANAPC1; APC1; MCPR; TSG24
Reactivity
Human, Mouse, Rat
Applications
Immunohistochemistry, Immunofluorescence, ELISA
Purity
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Synonyms
APC1; APC1 Antibody; ANAPC1; ANC1; Anaphase promoting complex subunit 1; Cyclosome subunit 1; Mitotic checkpoint regulator; Protein Tsg24; TSG24; anti-APC1 antibody
Ordering
For Research Use Only!
Reactivity
Human, Mouse, Rat
Specificity
APC1 antibody detects endogenous levels of total APC1 protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Sequence Length
1944
Applicable Applications for anti-APC1 antibody
Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)
Application Notes
IHC: 1:50-1:100
IF: 1:100-1:500
ELISA: 1:10000
Immunogen
The antiserum was produced against synthesized peptide derived from Internal of human APC1.
Preparation and Storage
Store at-20 degree C for 1 year.

Testing Data

(Peptide-+)

Testing Data (Peptide-+)

Immunohistochemistry (IHC)

(Peptide-+ Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using APC1 antibody. Immunofluorescence analysis of HepG2 cells, using APC1 antibody.)

Immunohistochemistry (IHC) (Peptide-+ Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using APC1 antibody. Immunofluorescence analysis of HepG2 cells, using APC1 antibody.)
References
Yashi Ahmed, Development, Apr 2002; 129: 1751. Praveen Kumar, J. Biol. Chem., Sep 2005; 280: 31783-31791. Rebecca A. Green, Mol. Biol. Cell, Oct 2005; 16: 4609-4622.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
216,500 Da
NCBI Official Full Name
anaphase-promoting complex subunit 1
NCBI Official Synonym Full Names
anaphase promoting complex subunit 1
NCBI Official Symbol
ANAPC1
NCBI Official Synonym Symbols
APC1; MCPR; TSG24
NCBI Protein Information
anaphase-promoting complex subunit 1
UniProt Protein Name
Anaphase-promoting complex subunit 1
Protein Family
UniProt Gene Name
ANAPC1
UniProt Synonym Gene Names
TSG24; APC1

NCBI Description

This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. [provided by RefSeq, Dec 2011]

Uniprot Description

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Research Articles on APC1

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Product Notes

The APC1 anapc1 (Catalog #AAA8509709) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The APC1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's APC1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA). IHC: 1:50-1:100 IF: 1:100-1:500 ELISA: 1:10000. Researchers should empirically determine the suitability of the APC1 anapc1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "APC1, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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