anti-Human TRIM33 Antibody | anti-TRIM33 antibody

TRIM33 Antibody

Cat. Num. AAA850474

• Gene Names: SMAD1; BSP1; JV41; BSP-1; JV4-1; MADH1; MADR1
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Protein G-Sepharose affinity purified.
• Synonyms: TRIM33; TRIM33 Antibody; Mouse monoclonal IgG to TRIM33; anti-TRIM33 antibody

• Reactivity: Human
• Purity/Purification: Protein G-Sepharose affinity purified.
• Form/Format: Liquid
• Sequence Length: 465

• Applicable Applications for anti-TRIM33 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: ELISA: 1:5000-1:20000; WB: 1:100-1:2000
• Immunogen: Recombinant fragment of human TRIM33 (C-terminus).
• Preservative: 0.02% Sodium Azide and 50% glycerol, 1% BSA, PBS, pH7.4.
• Cellular Localization: Nucleus
• Preparation and Storage: Aliquot and store at-20 degree C. Avoid repeated freeze/thaw cycles.

Testing Data

(TRIM33 (C-terminus) antibody at 1/1000 dilution. Lane1: MCF7 whole cell lysate 40ug/lane. Lane2: Hela NE whole cell lysate 40ug/lane. Lane3: Hela whole cell lysate 40ug/lane. Predicted band size: 120KDa. Observed band size: 120KDa.)

Related Product Information for anti-TRIM33 antibody

The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. The protein is a member of the tripartite motif family. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined.

Product Categories/Family for anti-TRIM33 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

NCBI and Uniprot Product Information

• NCBI GI #: 51173727
• NCBI GeneID: 4086
• NCBI Accession #: NP_001003688.1
• NCBI GenBank Nucleotide #: NM_015906.3
• UniProt Accession #: Q15797; Q16636; Q9UFT8; A8KAJ0; D3DNZ9
• Molecular Weight: 15,406 Da
• NCBI Official Full Name: mothers against decapentaplegic homolog 1
• NCBI Official Synonym Full Names: SMAD family member 1
• NCBI Official Symbol: SMAD1
• NCBI Official Synonym Symbols: BSP1; JV41; BSP-1; JV4-1; MADH1; MADR1
• NCBI Protein Information: mothers against decapentaplegic homolog 1
• UniProt Protein Name: Mothers against decapentaplegic homolog 1
• Protein Family: E3 ubiquitin-protein ligase
• UniProt Gene Name: SMAD1
• UniProt Synonym Gene Names: BSP1; MADH1; MADR1; MAD homolog 1; Mothers against DPP homolog 1; SMAD 1; Smad1; hSMAD1; BSP-1

NCBI Description

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

Uniprot Description

Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression.