Mouse anti-Human CD80 Antibody | anti-CD80 antibody

CD80 Antibody

Cat. Num. AAA850069

• Gene Names: CD80; B7; BB1; B7-1; B7.1; LAB7; CD28LG; CD28LG1
• Reactivity: Human
• Applications: Immunofluorescence, Immunohistochemistry, ELISA
• Synonyms: CD80; CD80 Antibody; CD28LG; LAB7; B7.1; anti-CD80 antibody

• Host: Mouse
• Reactivity: Human
• Isotype: IgG1
• Clone Number: 2A2
• Form/Format: Ascitic fluid containing 0.03% sodium azide.
• Sequence Length: 288

• Applicable Applications for anti-CD80 antibody: Immunofluorescence (IF), Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:200-1:1000; IF: 1:200-1:1000; ELISA: 1:10000
• Immunogen: Purified recombinant fragment of CD80 expressed in E. Coli.
• Preparation and Storage: Store at 4 degree C, for long term storage, store at-20 degree C

Immunohistochemistry (IHC)

(Figure 1. Immunohistochemical analysis of paraffin-embedded human Tonsil tissues using anti-CD80 mAb)

Immunofluorescence (IF)

(Figure 2. Confocal immunofluorescence analysis of BCBL-1 cells using anti-CD80 monoclonal antioby(green), showing membrane localization. Blue. DRAQ5 fluorescent DNA dye.)

Related Product Information for anti-CD80 antibody

The protein CD80 (Cluster of Differentiation 80) is a molecule found on activated B cells and monocytes which provides a costimulatory signal necessary for T cell activation and survival. It is also known as B7.1. Its principal mode of action is by binding to CD28. Along with CD86, these molecules provide the necessary stimuli to prime T cells against antigens presented by antigen-presenting cells. CD80 and CD86 also bind to CTLA-4, a cell surface molecule expressed on activated T cells. Interactions between CD80 or CD86 with CTLA-4 decrease the response of T cells. Mouse research by scientists at Emory University showed that estrogen-related bone loss is linked to recently discovered pathways involving various proteins, such as CD80 and other functions. In a nutshell, reactive oxygen stimulates dendritic cells, which activate other immune cells to up-regulate production of CD80, the molecule co-responsible for T cell activation. "When this pathway is activated, it leads to increased T cell TNF production and ultimately to bone loss." In turn, T cells produce a protein, Tumor Necrosis Factor, which increases the formation of osteoclasts in rodents and humans.

Product Categories/Family for anti-CD80 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

NCBI and Uniprot Product Information

• NCBI GI #: 4885123
• NCBI GeneID: 941
• NCBI Accession #: NP_005182.1
• NCBI GenBank Nucleotide #: NM_005191.3
• UniProt Accession #: P33681; Q5DTA9; Q5DTB0
• Molecular Weight: 55kDa
• NCBI Official Full Name: T-lymphocyte activation antigen CD80
• NCBI Official Synonym Full Names: CD80 molecule
• NCBI Official Symbol: CD80
• NCBI Official Synonym Symbols: B7; BB1; B7-1; B7.1; LAB7; CD28LG; CD28LG1
• NCBI Protein Information: T-lymphocyte activation antigen CD80
• UniProt Protein Name: T-lymphocyte activation antigen CD80
• Protein Family: T-lymphocyte activation antigen
• UniProt Gene Name: CD80
• UniProt Synonym Gene Names: CD28LG; CD28LG1; LAB7; B7

NCBI Description

The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011]

Uniprot Description

Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.