XMU-MP-1 Biochemical

XMU-MP-1

Cat. Num. AAA848772

• Purity: >=98%
• Synonyms: XMU-MP-1; XMU-MP1; XMUMP 1; 4- ( (5; 10-dimethyl-6-oxo-6; 10-dihydro-5H-pyrimido[5; 4-b]thieno[3; 2-e][1; 4]diazepin-2-yl) amino) benzenesulfonamid; XMU-MP-1 biochemical

• Purity/Purification: >=98%
• Form/Format: Crystalline solid

• Solubility: >30 mg/ml in DMSO
• Molecular Formula: C??H??N?O??S?
• CAS Number: 2061980-01-4
• PubChem CID: 121499143
• SMILES: CN1C2=C (C (=O)N (C3=CN=C (N=C31)NC4=CC=C (C=C4)S (=O)(=O)N)C)SC=C2
• InChi: InChI=1S/C17H16N6O3S2/c1-22-12-7-8-27-14 (12)16 (24)23 (2)13-9-19-17 (21-15 (13)22)20-10-3-5-11 (6-4-10)28 (18,25)26/h3-9H,1-2H3, (H2,18,25,26)(H,19,20,21)
• InChi Key: YRDHKIFCGOZTGD-UHFFFAOYSA-N
• Preparation and Storage: Store at -20 degree C; Shelf life: ~36 months

Structure

Related Product Information for XMU-MP-1 biochemical

XMU-MP-1 is a potent and selective ATP-competitive mammalian sterile 20-like kinase (MST) 1/2 inhibitor (IC50 values are 38.1 and 71.1 nM for MST2 and MST1, respectively). It is selective for MST1 and 2 over a panel of 468 kinases at a concentration of 1 uM. XMU-MP-1 inhibits phosphorylation of MOB1, LATS1 and 2, and YAP in HepG2 cells as well as MST1 and 2 autophosphorylation in RAW 264.7, U2OS, SW480, RPE1, SNU423, and HepG2 cells in a concentration-dependent manner. Enhances activity of downstream YAP in vitro.

Product Categories/Family for XMU-MP-1 biochemical

Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Kinase Inhibitors  (A-Z); Biochemicals; Biochemicals (A-Z); Protein Tyrosine Kinase Inhibitors; Enzyme Inhibitors (A-Z)

References

https://pubchem.ncbi.nlm.nih.gov/compound/121499143