Testing Data
Rabbit SETMAR Polyclonal Antibody | anti-SETMAR antibody
Anti-SETMAR Antibody
In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol and 0.01% sodium azide
IHC: 1:50- 1:200
The antibody solution should be gently mixed before use.
Testing Data
Testing Data
Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair; stalled replication fork restart and DNA integration. DNA-binding protein; it is indirectly recruited to sites of DNA damage through protein-protein interactions. Has also kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a fusion protein that contains an N-terminal histone-lysine N-methyltransferase domain and a C-terminal mariner transposase domain. The encoded protein binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The SET domain portion of this protein specifically methylates histone H3 lysines 4 and 36. This gene exists as a fusion gene only in anthropoid primates, other organisms lack mariner transposase domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Uniprot Description
SETMAR: Histone methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'. Has sequence-specific DNA-binding activity and recognizes the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element. Has DNA nicking activity. Has in vivo end joining activity and may mediate genomic integration of foreign DNA. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine
Chromosomal Location of Human Ortholog: 3p26.1
Cellular Component: condensed chromosome; nucleolus; nucleus
Molecular Function: DNA binding; double-stranded DNA binding; endonuclease activity; histone lysine N-methyltransferase activity (H3-K36 specific); histone lysine N-methyltransferase activity (H3-K4 specific); protein binding; protein homodimerization activity; single-stranded DNA binding; single-stranded DNA specific endodeoxyribonuclease activity
Biological Process: cell proliferation; DNA catabolic process, endonucleolytic; DNA double-strand break processing; DNA integration; double-strand break repair via nonhomologous end joining; histone H3-K36 methylation; histone H3-K4 methylation; replication fork processing
Research Articles on SETMAR
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Product Notes
The SETMAR setmar (Catalog #AAA846079) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-SETMAR Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's SETMAR can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB); Immunohistochemistry (IHC). WB: 1:500- 1:2000 IHC: 1:50- 1:200. Researchers should empirically determine the suitability of the SETMAR setmar for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SETMAR, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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