Rabbit CLIM-1 Polyclonal Antibody | anti-CLIM-1 antibody

Anti-CLIM-1 Antibody

Cat. Num. AAA8307129

• Gene Names: LDB2; LDB1; CLIM1
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Purified by Immunogen Affinity Chromatography
• Synonyms: CLIM-1; Polyclonal Antibody; Anti-CLIM-1 Antibody; CLIM1; LIM domain-binding protein 2; LDB-2; Carboxyl-terminal LIM domain-binding protein 1; LIM domain-binding factor CLIM1; anti-CLIM-1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: Recognizes endogenous levels of CLIM-1 protein.
• Purity/Purification: Purified by Immunogen Affinity Chromatography
• Form/Format: Liquid in 0.42% Potassium Phosphate, 0.87% Sodium Chloride, pH 7.3, 30% Glycerol, and 0.01% Sodium Azide.

• Applicable Applications for anti-CLIM-1 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: Recombinant fusion protein of human CLIM-1. The exact sequence is proprietary.
• Preparation and Storage: Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of CLIM-1 expression in Raji (A), mouse kidney (B) whole cell lysates.)

Related Product Information for anti-CLIM-1 antibody

Rabbit polyclonal antibody to CLIM-1

NCBI and Uniprot Product Information

• NCBI GI #: 4504971
• NCBI GeneID: 9079
• NCBI Accession #: NP_001281.1
• NCBI GenBank Nucleotide #: NM_001290.3
• UniProt Accession #: O43679; O55203
• Molecular Weight: 39,740 Da
• NCBI Official Full Name: LIM domain-binding protein 2 isoform a
• NCBI Official Synonym Full Names: LIM domain binding 2
• NCBI Official Symbol: LDB2
• NCBI Official Synonym Symbols: LDB1; CLIM1
• NCBI Protein Information: LIM domain-binding protein 2; LDB-2; CLIM-1; LIM binding domain 2; LIM domain-binding factor-2; LIM domain-binding factor CLIM1; carboxyl-terminal LIM domain-binding protein 1
• UniProt Protein Name: LIM domain-binding protein 2
• UniProt Gene Name: LDB2
• UniProt Synonym Gene Names: CLIM1; LDB-2; CLIM-1
• UniProt Entry Name: LDB2_HUMAN

NCBI Description

Genes encoding LIM domain-binding factors were initially isolated in a screen for proteins that physically interact with the LIM domains of nuclear proteins (summarized by Semina et al., 1998 [PubMed 9799849]). These proteins, such as the one encoded by the LDB2 gene, are capable of binding to a variety of transcription factors and are likely to function at enhancers to bring together diverse transcription factors and form higher order activation complexes or to block formation of such complexes (Jurata and Gill, 1997 [PubMed 9315627]). The family of genes encoding LIM domain-binding factors includes 2 members isolated from the mouse, Clim1 (Bach et al., 1997 [PubMed 9192866]) and Clim2/Lbd1/Nli (Agulnick et al., 1996 [PubMed 8918878]; Jurata et al., 1996 [PubMed 8876198]; Bach et al., 1997 [PubMed 9192866]) and their homologs cloned from the frog, chicken, and fly. The fact that LIM domain-binding factors are likely to be involved in the coordination of the transcriptional activity of many diverse factors might implicate them in human phenotypes characterized by multiple affected sites.[supplied by OMIM, Jul 2010]

Uniprot Description

LDB2: Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. Belongs to the LDB family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor; Cell development/differentiation

Chromosomal Location of Human Ortholog: 4p16

Cellular Component: transcription factor complex; nucleus

Molecular Function: LIM domain binding; enzyme binding; transcription cofactor activity

Biological Process: hair follicle development; somatic stem cell maintenance; positive regulation of transcription from RNA polymerase II promoter