Rabbit CBX6 Polyclonal Antibody | anti-CBX6 antibody

Anti-CBX6 Antibody

Cat. Num. AAA8305722

• Reactivity: Human, Mouse, Rat, Bovine, Dog
• Applications: Western Blot, Immunohistochemistry
• Purity: Purified by Immunogen Affinity Chromatography
• Synonyms: CBX6; Polyclonal Antibody; Anti-CBX6 Antibody; Chromobox protein homolog 6; anti-CBX6 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat, Bovine, Dog
• Clonality: Polyclonal
• Specificity: Recognizes endogenous levels of CBX6 protein.
• Purity/Purification: Purified by Immunogen Affinity Chromatography
• Form/Format: Liquid in 0.42% Potassium Phosphate, 0.87% Sodium Chloride, pH 7.3, 30% Glycerol, and 0.01% Sodium Azide.

• Applicable Applications for anti-CBX6 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:500-1:1000; IHC: 1:50-1:200
• Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human CBX6. The exact sequence is proprietary.
• Preparation and Storage: Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of CBX6 expression in HEK293T (A), HCT116 (B), mouse testis (C), rat kidney (D) whole cell lysates.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of CBX6 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.)

Related Product Information for anti-CBX6 antibody

Rabbit polyclonal antibody to CBX6

NCBI and Uniprot Product Information

• NCBI GI #: 46852392
• NCBI GeneID: 23466
• NCBI Accession #: NP_055107.3
• NCBI GenBank Nucleotide #: NM_014292.3
• UniProt Accession #: O95503; Q9DBY5
• Molecular Weight: 43,898 Da
• NCBI Official Full Name: chromobox protein homolog 6
• NCBI Official Synonym Full Names: chromobox homolog 6
• NCBI Official Symbol: CBX6
• NCBI Protein Information: chromobox protein homolog 6
• UniProt Protein Name: Chromobox protein homolog 6
• Protein Family: Chromobox protein
• UniProt Gene Name: CBX6
• UniProt Entry Name: CBX6_HUMAN

Uniprot Description

CBX6: Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Protein type: Transcription regulation

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: nucleoplasm; heterochromatin; PcG protein complex; nucleus

Molecular Function: protein binding; single-stranded RNA binding

Biological Process: transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; chromatin modification