STAB2 sirna

STAB2 siRNA (Mouse)

Cat. Num. AAA827824

• Gene Names: Stab2; FELL; FEEL-2; STAB-2; MFEEL-2
• Reactivity: Mouse
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: STAB2; STAB2 siRNA (Mouse); FEEL2; HARE; Stabilin-2; Fasciclin. EGF-like. laminin-type EGF-like and link domain-containing scavenger receptor 2; FEEL-2; STAB2 sirna

• Host: Synthetic
• Reactivity: Mouse
• Specificity: STAB2 siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 2,559

• Applicable Applications for STAB2 sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse STAB2 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for STAB2 sirna

siRNA to inhibit STAB2 expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 20149764
• NCBI GeneID: 192188
• NCBI Accession #: NP_619614.1
• NCBI GenBank Nucleotide #: NM_138673.2
• UniProt Accession #: Q8R4U0; Q8BM87
• Molecular Weight: 277,532 Da
• NCBI Official Full Name: stabilin-2
• NCBI Official Synonym Full Names: stabilin 2
• NCBI Official Symbol: Stab2
• NCBI Official Synonym Symbols: FELL; FEEL-2; STAB-2; MFEEL-2
• NCBI Protein Information: stabilin-2
• UniProt Protein Name: Stabilin-2
• Protein Family: Stabilin
• UniProt Gene Name: Stab2
• UniProt Synonym Gene Names: FEEL-2
• UniProt Entry Name: STAB2_MOUSE

Uniprot Description

STAB2: Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalisation as well as HA and CS.

Protein type: Membrane protein, integral; Receptor, misc.

Cellular Component: membrane; integral to plasma membrane; cytoplasm; integral to membrane; plasma membrane; external side of plasma membrane

Molecular Function: low-density lipoprotein receptor activity; hyaluronic acid binding; low-density lipoprotein binding; scavenger receptor activity

Biological Process: receptor-mediated endocytosis; regulation of gene expression; regulation of blood coagulation; defense response to bacterium; endocytosis; cell adhesion