BMPR1A recombinant protein

Recombinant Mouse BMPR1A Protein

Cat. Num. AAA8248613

• Gene Names: Bmpr1a; ALK3; Bmpr; BMPR-IA; AU045487; 1110037I22Rik
• Reactivity: Mouse
• Applications: ELISA, Western Blot, SDS-Page
• Purity: Greater than 95% as determined by reducing SDS-PAGE.
• Synonyms: BMPR1A; Recombinant Mouse BMPR1A Protein; ACVRLK3; ALK3; Bone morphogenetic protein receptor type-1A; BMP type-1A receptor; BMPR-1A; Activin receptor-like kinase 3; ALK-3; Serine/threonine-protein kinase receptor R5; SKR5; CD292; BMPR1A recombinant protein

• Host: Human cells
• Reactivity: Mouse
• Purity/Purification: Greater than 95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 muM filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
• Sequence: QNLDSMLHGT GMKSDLDQKK PENGVTLAPE DTLPFLKCYC SGHCPDDAIN NTCITNGHCF AIIEEDDQGE TTLTSGCMKY EGSDFQCKDS PKAQLRRTIE CCRTNLCNQY LQPTLPPVVI GPFFDGSIRV DDIEGRMDEP KSCDKTHTCP PCPAPELLGG PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSREE MTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW QQGNVFSCSV MHEALHNHYT QKSLSLSPGK HHHHHH
• Sequence Length: 532

• Applicable Applications for BMPR1A recombinant protein: ELISA (EIA),Western Blot (WB), SDS-PAGE, Mass Spectrometry (MS)
• Endotoxin: Less than 0.1 ng/mug (1 IEU/mug) as determined by LAL test.
• Directions for Use: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 mug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Preparation and Storage: Lyophilized protein should be stored at -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 2-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at -20 degree C for 3 months.

Related Product Information for BMPR1A recombinant protein

Recombinant Mouse BMPR1A Protein is produced by our mammalian expression system and the target gene encoding Gln24-Arg152 is expressed with a Fc, 6His tag at the C-terminus.

NCBI and Uniprot Product Information

• NCBI GI #: 46519168
• NCBI GeneID: 12166
• NCBI Accession #: NP_033888.2
• NCBI GenBank Nucleotide #: NM_009758.4
• UniProt Accession #: P36895
• Molecular Weight: 60,063 Da
• NCBI Official Full Name: bone morphogenetic protein receptor type-1A
• NCBI Official Synonym Full Names: bone morphogenetic protein receptor, type 1A
• NCBI Official Symbol: Bmpr1a
• NCBI Official Synonym Symbols: ALK3; Bmpr; BMPR-IA; AU045487; 1110037I22Rik
• NCBI Protein Information: bone morphogenetic protein receptor type-1A
• UniProt Protein Name: Bone morphogenetic protein receptor type-1A
• Protein Family: Bone morphogenetic protein receptor
• UniProt Gene Name: Bmpr1a
• UniProt Synonym Gene Names: Acvrlk3; Bmpr; BMP type-1A receptor; BMPR-1A; ALK-3; SKR5
• UniProt Entry Name: BMR1A_MOUSE

Uniprot Description

BMPR1A: a serine/threonine-protein kinase receptor for Bone morphogenetic protein-2 and -4 (BMP-2 and BMP-4). Defects in BMPR1A are a cause of juvenile polyposis syndrome (JPS) and Cowden disease (CD), a cancer syndrome characterized by multiple hamartomas and by a high risk for breast, thyroid and endometriel cancers.

Protein type: EC 2.7.11.30; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; STKR family; TKL group; Type1 subfamily

Cellular Component: caveola; cell soma; dendrite; external side of plasma membrane; plasma membrane

Molecular Function: ATP binding; glycoprotein binding; protein binding; protein homodimerization activity; protein serine/threonine kinase activity; SMAD binding

Biological Process: anterior/posterior pattern formation; BMP signaling pathway; cartilage development; cell differentiation; chondrocyte differentiation; developmental growth; dorsal/ventral axis specification; dorsal/ventral pattern formation; ectoderm development; embryonic digit morphogenesis; embryonic morphogenesis; embryonic organ development; endoderm development; heart development; heart morphogenesis; hindlimb morphogenesis; immune response; in utero embryonic development; lateral mesoderm development; lung development; mesendoderm development; mesoderm formation; Mullerian duct regression; negative regulation of neurogenesis; negative regulation of smooth muscle cell migration; nervous system development; neural crest cell development; neural plate mediolateral pattern formation; odontogenesis of dentine-containing teeth; palate development; paraxial mesoderm development; paraxial mesoderm structural organization; pattern specification process; pituitary gland development; positive regulation of bone mineralization; positive regulation of cardiac muscle cell proliferation; positive regulation of epithelial cell proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; regulation of cardiac muscle cell proliferation; regulation of endothelial cell differentiation; regulation of endothelial cell proliferation; regulation of lateral mesodermal cell fate specification; somitogenesis; stem cell maintenance