Rabbit anti-Human, Mouse PGD Polyclonal Antibody | anti-PGD antibody
Anti-PGD Antibody
NCBI and Uniprot Product Information
NCBI Description
6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]
Uniprot Description
PGD: an oxidative carboxylase that catalyses the decarboxylating reduction of 6-phosphogluconate into ribulose 5-phosphate in the presence of NADP. This reaction is a component of the hexose mono-phosphate shunt and pentose phosphate pathways.
Protein type: Other Amino Acids Metabolism - glutathione; Oxidoreductase; EC 1.1.1.44; Carbohydrate Metabolism - pentose phosphate pathway
Chromosomal Location of Human Ortholog: 1p36.22
Cellular Component: cytosol; nucleus
Molecular Function: phosphogluconate dehydrogenase (decarboxylating) activity
Biological Process: pentose-phosphate shunt; pentose-phosphate shunt, oxidative branch