Typical Testing Data/Standard Curve (for reference only)
Mouse MMP2 ELISA Kit | MMP2 elisa kit
Mouse MMP2 ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
NCBI and Uniprot Product Information
Uniprot Description
MMP2: Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Interacts (via the C-terminal hemopexin-like domains- containing region) with the integrin alpha-V/beta-3; the interaction promotes vascular invasion in angiogenic vessels and melamoma cells. Interacts (via the C-terminal PEX domain) with TIMP2 (via the C-terminal); the interaction inhibits the degradation activity. Interacts with GSK3B. Aspirin appears to inhibit expression. Produced by normal skin fibroblasts. PEX is expressed in a number of tumors including gliomas, breast and prostate. Inhibited by histatin-3 1/24 (histatin-5). Belongs to the peptidase M10A family.
Protein type: EC 3.4.24.24; Secreted; Protease; Apoptosis; Secreted, signal peptide; Cell development/differentiation; Motility/polarity/chemotaxis
Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; sarcomere; membrane; mitochondrion; cytoplasm; extracellular region; plasma membrane; nucleus
Molecular Function: peptidase activity; hydrolase activity; zinc ion binding; metallopeptidase activity; metalloendopeptidase activity; metal ion binding; fibronectin binding
Biological Process: response to drug; cell migration; intramembranous ossification; positive regulation of apoptosis; tissue remodeling; negative regulation of cell adhesion; proteolysis; blood vessel maturation; axon regeneration in the peripheral nervous system; negative regulation of vasoconstriction; collagen catabolic process; ovarian follicle development; response to hydrogen peroxide; skeletal morphogenesis; response to mechanical stimulus; response to estrogen stimulus; positive regulation of innate immune response; response to hypoxia; response to oxidative stress; angiogenesis; embryo implantation; positive regulation of cell migration
Research Articles on MMP2
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Product Notes
The Mouse MMP2 mmp2 (Catalog #AAA824667) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA824667 ELISA Kit recognizes Mouse MMP2. AAA Biotech's MMP2 can be used in a range of immunoassay formats including, but not limited to, Sandwich ELISA (SE). Researchers should empirically determine the suitability of the MMP2 mmp2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MMP2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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